Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell Counts
Joint Authors
Puzianowska-Kuznicka, Monika
Sieroń, Aleksander L.
Gutmajster, Ewa
Witecka, Joanna
Wyskida, Magdalena
Koscinska-Marczewska, Justyna
Szwed, Malgorzata
Owczarz, Magdalena
Mossakowska, Malgorzata
Milewicz, Andrzej
Zejda, Jan
Chudek, Jerzy
Więcek, Andrzej
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Age-related decrease in bone marrow erythropoietic capacity is often accompanied by the telomere length shortening in peripheral white blood cells.
However, limited and conflicting data hamper the conclusive opinion regarding this relationship.
Therefore, the aim of this study was to assess an association between telomere length and peripheral blood cell count parameters in the Polish elderly population.
Material and Methods.
The substudy included 1573 of 4981 subjects aged 65 years or over, participants of the population-based PolSenior study.
High-molecular-weight DNA was isolated from blood mononuclear cells.
Telomere length (TL) was measured by QRT-PCR as abundance of telomere template versus a single gene copy encoding acidic ribosomal phosphoprotein P0.
Results.
Only white blood count (WBC) was significantly different in TL tertile subgroups in all subjects (P=0.02) and in men (P=0.01), but not in women.
Merely in men significant but weak positive correlations were found between TL and WBC (r=0.11, P<0.05) and RBC (r=0.08, P<0.05).
The multiple regression analysis models confirmed a weak, independent contribution of TL to both RBC and WBC.
Conclusions.
In the elderly, telomere shortening limits hematopoiesis capacity to a very limited extent.
American Psychological Association (APA)
Gutmajster, Ewa& Witecka, Joanna& Wyskida, Magdalena& Koscinska-Marczewska, Justyna& Szwed, Malgorzata& Owczarz, Magdalena…[et al.]. 2013. Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell Counts. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032578
Modern Language Association (MLA)
Gutmajster, Ewa…[et al.]. Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell Counts. The Scientific World Journal No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1032578
American Medical Association (AMA)
Gutmajster, Ewa& Witecka, Joanna& Wyskida, Magdalena& Koscinska-Marczewska, Justyna& Szwed, Malgorzata& Owczarz, Magdalena…[et al.]. Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell Counts. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032578