![](/images/graphics-bg.png)
Genetic Structure and Expression of the Surface Glycoprotein GP82, the Main Adhesin of Trypanosoma cruzi Metacyclic Trypomastigotes
Joint Authors
Correa, Paulo Roberto Ceridorio
Cordero, Esteban Mauricio
Gentil, Luciana Girotto
Bayer-Santos, Ethel
Silveira, José F.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
T.
cruzi improves the likelihood of invading or adapting to the host through its capacity to present a large repertoire of surface molecules.
The metacyclic stage-specific surface glycoprotein GP82 has been implicated in host cell invasion.
GP82 is encoded by multiple genes from the trans-sialidase superfamily.
GP82 shows a modular organization, with some variation of N-terminal region flanking a conserved central core where the binding sites to the mammalian cell and gastric mucin are located.
The function of GP82 as adhesin in host cell invasion process could expose the protein to an intense conservative and selective pressure.
GP82 is a GPI-anchored surface protein, synthesized as a 70 kDa precursor devoid of N-linked sugars.
GPI-minus variants accumulate in the ER indicating that GPI anchor acts as a forward transport signal for progressing along the secretory pathway as suggested for T.
cruzi mucins.
It has been demonstrated that the expression of GP82 is constitutive and may be regulated at post-transcriptional level, for instance, at translational level and/or mRNA stabilization.
GP82 mRNAs are mobilized to polysomes and consequently translated, but only in metacyclic trypomastigotes.
Analysis of transgenic parasites indicates that the mechanism regulating GP82 expression involves multiple elements in the 3′UTR.
American Psychological Association (APA)
Correa, Paulo Roberto Ceridorio& Cordero, Esteban Mauricio& Gentil, Luciana Girotto& Bayer-Santos, Ethel& Silveira, José F.. 2013. Genetic Structure and Expression of the Surface Glycoprotein GP82, the Main Adhesin of Trypanosoma cruzi Metacyclic Trypomastigotes. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1032582
Modern Language Association (MLA)
Correa, Paulo Roberto Ceridorio…[et al.]. Genetic Structure and Expression of the Surface Glycoprotein GP82, the Main Adhesin of Trypanosoma cruzi Metacyclic Trypomastigotes. The Scientific World Journal No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1032582
American Medical Association (AMA)
Correa, Paulo Roberto Ceridorio& Cordero, Esteban Mauricio& Gentil, Luciana Girotto& Bayer-Santos, Ethel& Silveira, José F.. Genetic Structure and Expression of the Surface Glycoprotein GP82, the Main Adhesin of Trypanosoma cruzi Metacyclic Trypomastigotes. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1032582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032582