Association of FAS and FAS Ligand Genes Polymorphism and Risk of Systemic Lupus Erythematosus
Joint Authors
Sandoughi, Mahnaz
Salimi, Saeedeh
Moudi, Bita
Zakeri, Zahra
Farajian-Mashhadi, Farzaneh
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
FAS/FASL pathway plays a critical role in maintaining peripheral immune tolerance; therefore, the apoptosis genes, Fas and Fas ligand (FasL), could be suitable candidate genes in human SLE susceptibility.
Materials and Methods.
In this case-control study, 106 SLE patients and 149 sex, age, and ethnicity matched healthy controls were genotyped for the Fas A-670G and FasLC-844T polymorphisms by polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP).
Results.
The frequency of -670AA genotype was significantly higher in SLE patients than control group and the risk of SLE was 2.1-fold greater in subjects with AA genotype (P=0.03).
The frequency of -670A allele was significantly higher in SLE patients than in controls too (58% versus 49%, P=0.03).
The -844CC genotype frequency was significantly higher in SLE patients than in healthy controls and the risk of SLE was 2.8-fold greater in these subjects (P=0.01).
The C allele frequency was significantly higher in patients than in controls (69% versus 49%, P=0.001).
Increased SLE risk was observed in individuals with combined effect of Fas-670AA and FasL-844CC genotypes (P=0.001).
Conclusion.
Fas-670AA and FasL-844CC genotypes were associated with SLE risk, and combined effect of -670AA and -844CC genotypes might increase SLE susceptibility.
American Psychological Association (APA)
Moudi, Bita& Salimi, Saeedeh& Farajian-Mashhadi, Farzaneh& Sandoughi, Mahnaz& Zakeri, Zahra. 2013. Association of FAS and FAS Ligand Genes Polymorphism and Risk of Systemic Lupus Erythematosus. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1032623
Modern Language Association (MLA)
Moudi, Bita…[et al.]. Association of FAS and FAS Ligand Genes Polymorphism and Risk of Systemic Lupus Erythematosus. The Scientific World Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1032623
American Medical Association (AMA)
Moudi, Bita& Salimi, Saeedeh& Farajian-Mashhadi, Farzaneh& Sandoughi, Mahnaz& Zakeri, Zahra. Association of FAS and FAS Ligand Genes Polymorphism and Risk of Systemic Lupus Erythematosus. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1032623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032623