Biophysical Insights into Cancer Transformation and Treatment
Joint Authors
Foletti, Alberto
Pokorný, Jiří
Kobilková, Jitka
Jandová, Anna
Vrba, Jan
Vrba, Jan
Nedbalová, Martina
Čoček, Aleš
Danani, Andrea
Tuszyński, Jack A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Biological systems are hierarchically self-organized complex structures characterized by nonlinear interactions.
Biochemical energy is transformed into work of physical forces required for various biological functions.
We postulate that energy transduction depends on endogenous electrodynamic fields generated by microtubules.
Microtubules and mitochondria colocalize in cells with microtubules providing tracks for mitochondrial movement.
Besides energy transformation, mitochondria form a spatially distributed proton charge layer and a resultant strong static electric field, which causes water ordering in the surrounding cytosol.
These effects create conditions for generation of coherent electrodynamic field.
The metabolic energy transduction pathways are strongly affected in cancers.
Mitochondrial dysfunction in cancer cells (Warburg effect) or in fibroblasts associated with cancer cells (reverse Warburg effect) results in decreased or increased power of the generated electromagnetic field, respectively, and shifted and rebuilt frequency spectra.
Disturbed electrodynamic interaction forces between cancer and healthy cells may favor local invasion and metastasis.
A therapeutic strategy of targeting dysfunctional mitochondria for restoration of their physiological functions makes it possible to switch on the natural apoptotic pathway blocked in cancer transformed cells.
Experience with dichloroacetate in cancer treatment and reestablishment of the healthy state may help in the development of novel effective drugs aimed at the mitochondrial function.
American Psychological Association (APA)
Pokorný, Jiří& Foletti, Alberto& Kobilková, Jitka& Jandová, Anna& Vrba, Jan& Vrba, Jan…[et al.]. 2013. Biophysical Insights into Cancer Transformation and Treatment. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1032642
Modern Language Association (MLA)
Pokorný, Jiří…[et al.]. Biophysical Insights into Cancer Transformation and Treatment. The Scientific World Journal No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1032642
American Medical Association (AMA)
Pokorný, Jiří& Foletti, Alberto& Kobilková, Jitka& Jandová, Anna& Vrba, Jan& Vrba, Jan…[et al.]. Biophysical Insights into Cancer Transformation and Treatment. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1032642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032642