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Antitumor Activity of Human Hydatid Cyst Fluid in a Murine Model of Colon Cancer
Joint Authors
Berriel, Edgardo
Russo, Sofía
Monin, Leticia
Festari, María Florencia
Berois, Nora
Fernández, Gabriel
Freire, Teresa
Osinaga, Eduardo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
This study evaluates the antitumor immune response induced by human hydatic cyst fluid (HCF) in an animal model of colon carcinoma.
We found that anti-HCF antibodies were able to identify cell surface and intracellular antigens in CT26 colon cancer cells.
In prophylactic tumor challenge experiments, HCF vaccination was found to be protective against tumor formation for 40% of the mice (P=0.01).
In the therapeutic setting, HCF vaccination induced tumor regression in 40% of vaccinated mice (P=0.05).
This vaccination generated memory immune responses that protected surviving mice from tumor rechallenge, implicating the development of an adaptive immune response in this process.
We performed a proteomic analysis of CT26 antigens recognized by anti-HCF antibodies to analyze the immune cross-reactivity between E.
granulosus (HCF) and CT26 colon cancer cells.
We identified two proteins: mortalin and creatine kinase M-type.
Interestingly, CT26 mortalin displays 60% homology with E.
granulosus hsp70.
In conclusion, our data demonstrate the capacity of HCF vaccination to induce antitumor immunity which protects from tumor growth in an animal model.
This new antitumor strategy could open new horizons in the development of highly immunogenic anticancer vaccines.
American Psychological Association (APA)
Berriel, Edgardo& Russo, Sofía& Monin, Leticia& Festari, María Florencia& Berois, Nora& Fernández, Gabriel…[et al.]. 2013. Antitumor Activity of Human Hydatid Cyst Fluid in a Murine Model of Colon Cancer. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1032677
Modern Language Association (MLA)
Berriel, Edgardo…[et al.]. Antitumor Activity of Human Hydatid Cyst Fluid in a Murine Model of Colon Cancer. The Scientific World Journal No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1032677
American Medical Association (AMA)
Berriel, Edgardo& Russo, Sofía& Monin, Leticia& Festari, María Florencia& Berois, Nora& Fernández, Gabriel…[et al.]. Antitumor Activity of Human Hydatid Cyst Fluid in a Murine Model of Colon Cancer. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1032677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032677