Genotoxicity Assessment of Multispecies Probiotics Using Reverse Mutation, Mammalian Chromosomal Aberration, and Rodent Micronucleus Tests
Joint Authors
Chiu, Yi-Jen
Nam, Mun-Kit
Tsai, Yueh-Ting
Huang, Chun-Chi
Tsai, Cheng-Chih
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Genotoxicity assessment is carried out on freeze dried powder of cultured probiotics containing Lactobacillus rhamnosus LCR177, Bifidobacterium adolescentis BA286, and Pediococcus acidilactici PA318.
Ames tests, in vitro mammalian chromosome aberration assay, and micronucleus tests in mouse peripheral blood are performed.
For 5 strains of Salmonella Typhimurium, the Ames tests show no increased reverse mutation upon exposure to the test substance.
In CHO cells, the frequency of chromosome aberration does not increase in responding to the treatment of probiotics.
Likewise, the frequency of micronucleated reticulocytes in probiotics-fed mice is indistinguishable from that in the negative control group.
Taken together, the toxicity assessment studies suggest that the multispecies probiotic mixture does not have mutagenic effects on various organisms.
American Psychological Association (APA)
Chiu, Yi-Jen& Nam, Mun-Kit& Tsai, Yueh-Ting& Huang, Chun-Chi& Tsai, Cheng-Chih. 2013. Genotoxicity Assessment of Multispecies Probiotics Using Reverse Mutation, Mammalian Chromosomal Aberration, and Rodent Micronucleus Tests. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1032703
Modern Language Association (MLA)
Chiu, Yi-Jen…[et al.]. Genotoxicity Assessment of Multispecies Probiotics Using Reverse Mutation, Mammalian Chromosomal Aberration, and Rodent Micronucleus Tests. The Scientific World Journal No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1032703
American Medical Association (AMA)
Chiu, Yi-Jen& Nam, Mun-Kit& Tsai, Yueh-Ting& Huang, Chun-Chi& Tsai, Cheng-Chih. Genotoxicity Assessment of Multispecies Probiotics Using Reverse Mutation, Mammalian Chromosomal Aberration, and Rodent Micronucleus Tests. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1032703
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032703