Synthesis and Biological Evaluation of 2-Hydroxy-3-[(2-aryloxyethyl)amino]propyl 4-[(Alkoxycarbonyl)amino]benzoates
Joint Authors
Kollar, Peter
Tengler, Jan
Kapustíková, Iva
Peško, Matúš
Govender, Rodney
Keltošová, Stanislava
Mokrý, Petr
Král'ová, Katarína
O'Mahony, Jim M.
Coffey, Aidan
Jampilek, Josef
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
A series of twenty substituted 2-hydroxy-3-[(2-aryloxyethyl)amino]propyl 4-[(alkoxycarbonyl)amino]benzoates were prepared and characterized.
As similar compounds have been described as potential antimycobacterials, primary in vitro screening of the synthesized carbamates was also performed against two mycobacterial species.
2-Hydroxy-3-[2-(2,6-dimethoxyphenoxy)ethylamino]-propyl 4-(butoxycarbonylamino)benzoate hydrochloride, 2-hydroxy-3-[2-(4-methoxyphenoxy)ethylamino]-propyl 4-(butoxycarbonylamino)benzoate hydrochloride, and 2-hydroxy-3-[2-(2-methoxyphenoxy)ethylamino]-propyl 4-(butoxycarbonylamino)benzoate hydrochloride showed higher activity against M.
avium subsp.
paratuberculosis and M.
intracellulare than the standards ciprofloxacin, isoniazid, or pyrazinamide.
Cytotoxicity assay of effective compounds was performed using the human monocytic leukaemia THP-1 cell line.
Compounds with predicted amphiphilic properties were also tested for their effects on the rate of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts.
All butyl derivatives significantly stimulated the rate of PET, indicating that the compounds can induce conformational changes in thylakoid membranes resulting in an increase of their permeability and so causing uncoupling of phosphorylation from electron transport.
American Psychological Association (APA)
Tengler, Jan& Kapustíková, Iva& Peško, Matúš& Govender, Rodney& Keltošová, Stanislava& Mokrý, Petr…[et al.]. 2013. Synthesis and Biological Evaluation of 2-Hydroxy-3-[(2-aryloxyethyl)amino]propyl 4-[(Alkoxycarbonyl)amino]benzoates. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1032728
Modern Language Association (MLA)
Tengler, Jan…[et al.]. Synthesis and Biological Evaluation of 2-Hydroxy-3-[(2-aryloxyethyl)amino]propyl 4-[(Alkoxycarbonyl)amino]benzoates. The Scientific World Journal No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1032728
American Medical Association (AMA)
Tengler, Jan& Kapustíková, Iva& Peško, Matúš& Govender, Rodney& Keltošová, Stanislava& Mokrý, Petr…[et al.]. Synthesis and Biological Evaluation of 2-Hydroxy-3-[(2-aryloxyethyl)amino]propyl 4-[(Alkoxycarbonyl)amino]benzoates. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1032728
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032728