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Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential
Joint Authors
Lima, Larissa Lavorato
Lima, Rebeca Mól
Silva, Annelisa Farah da
Carmo, Antônio Márcio Resende do
Silva, Adilson David da
Barbosa Raposo, Nádia R.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
This research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol.
Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps.
The results showed the analog C as being the most powerful tyrosinase inhibitor (IA50 = 65.67 ± 0.60 μg/mL), followed by the analogs B, E, F, A, and D, respectively.
The analog C presented a tyrosinase inhibition potential better than natural resveratrol (P<0.001).
The best depigmenting activity was provided by the presence of hydroxyl in the orthoposition on the second phenolic ring.
American Psychological Association (APA)
Lima, Larissa Lavorato& Lima, Rebeca Mól& Silva, Annelisa Farah da& Carmo, Antônio Márcio Resende do& Silva, Adilson David da& Barbosa Raposo, Nádia R.. 2013. Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1032729
Modern Language Association (MLA)
Lima, Larissa Lavorato…[et al.]. Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential. The Scientific World Journal No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1032729
American Medical Association (AMA)
Lima, Larissa Lavorato& Lima, Rebeca Mól& Silva, Annelisa Farah da& Carmo, Antônio Márcio Resende do& Silva, Adilson David da& Barbosa Raposo, Nádia R.. Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1032729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032729