Evaluation of Genotoxic Effects of New Molecules with Possible Trypanocidal Activity for Chagas Disease Treatment
Joint Authors
Alessandra Fortes Aiub, Claudia
Felzenszwalb, Israel
Mello, Francisco V. C.
Carvalho, Alcione S.
Bastos, Mônica M.
Boechat, Nubia
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Chagas disease is responsible for a large number of human infections and many are also at risk of infection.
There is no effective drug for Chagas disease treatment.
The Institute of Pharmaceutical Technology at Fiocruz, Brazil, has designed three nitro analogs of the nitroimidazole-thiadiazole, megazol: two triazole analogs PTAL 05-02 and PAMT 09 and a pyrazole analog PTAL 04-09.
A set of Salmonella enterica serovar Typhimurium strains were used in the bacterial reverse mutation test (Ames test) to determine the mutagenicity and cytotoxicity of megazol and its nitro analogs.
Megazol presented positive mutagenic activity at very low concentration, either with or without metabolic activation S9 mix.
The mutagenic response of the analogs was detected at higher concentration than the lowest megazol concentration to yield mutagenic activity showing that new advances can be made to develop new analogs.
The micronucleus test with rat macrophage cells was used in the genotoxic evaluation.
The analogs were capable of inducing micronucleus formation and showed cytotoxic effects.
PTAL 04-09 structural modifications might be better suitable for the design of promising new drugs candidate for Chagas’ disease treatment.
American Psychological Association (APA)
Mello, Francisco V. C.& Carvalho, Alcione S.& Bastos, Mônica M.& Boechat, Nubia& Alessandra Fortes Aiub, Claudia& Felzenszwalb, Israel. 2013. Evaluation of Genotoxic Effects of New Molecules with Possible Trypanocidal Activity for Chagas Disease Treatment. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032750
Modern Language Association (MLA)
Mello, Francisco V. C.…[et al.]. Evaluation of Genotoxic Effects of New Molecules with Possible Trypanocidal Activity for Chagas Disease Treatment. The Scientific World Journal No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1032750
American Medical Association (AMA)
Mello, Francisco V. C.& Carvalho, Alcione S.& Bastos, Mônica M.& Boechat, Nubia& Alessandra Fortes Aiub, Claudia& Felzenszwalb, Israel. Evaluation of Genotoxic Effects of New Molecules with Possible Trypanocidal Activity for Chagas Disease Treatment. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032750