The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis
Joint Authors
Koca, Uğur
Olguner, Çimen Gülben
Altekin, Emel
Taşdöğen, Aydın
Duru, Seden
Girgin, Pelin
Gündüz, Kerim
Cilaker Mıcılı, Serap
Güzeldağ, Seda
Akkuş, Muhammed
Ergur, Bekir Ugur
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
In the present study, the effects of dexmedetomidine on secondary lung and kidney injuries were studied in the rat model of intra-abdominal sepsis by immunohistological and biochemical examinations.
We measured serum creatinine, kidney tissue malondialdehide and plasma neutrophil gelatinase-associated lipocalin levels.
In order to evaluate tissue injury we determined kidney tissue mononuclear cell infiltration score, alveolar macrophage count, histological kidney and lung injury scores and kidney and lung tissue immunoreactivity scores.
We demonstrated that dexmedetomidine attenuates sepsis-induced lung and kidney injuries and apoptosis in the rat model of sepsis.
There is still need for comparative studies in order to determine the effects of dexmedetomidine on organ functions in early human sepsis.
American Psychological Association (APA)
Koca, Uğur& Olguner, Çimen Gülben& Ergur, Bekir Ugur& Altekin, Emel& Taşdöğen, Aydın& Duru, Seden…[et al.]. 2013. The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1032755
Modern Language Association (MLA)
Koca, Uğur…[et al.]. The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis. The Scientific World Journal No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1032755
American Medical Association (AMA)
Koca, Uğur& Olguner, Çimen Gülben& Ergur, Bekir Ugur& Altekin, Emel& Taşdöğen, Aydın& Duru, Seden…[et al.]. The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1032755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032755