Thiamine Deficiency Induced Neurochemical, Neuroanatomical, and Neuropsychological Alterations: A Reappraisal
Joint Authors
Golaszewski, Stefan
Höller, Yvonne
Storti, Monica
Christova, Monica
Trinka, Eugen
Brigo, Francesco
Nardone, Raffaele
Tezzon, Frediano
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Nutritional deficiency can cause, mainly in chronic alcoholic subjects, the Wernicke encephalopathy and its chronic neurological sequela, the Wernicke-Korsakoff syndrome (WKS).
Long-term chronic ethanol abuse results in hippocampal and cortical cell loss.
Thiamine deficiency also alters principally hippocampal- and frontal cortical-dependent neurochemistry; moreover in WKS patients, important pathological damage to the diencephalon can occur.
In fact, the amnesic syndrome typical for WKS is mainly due to the damage in the diencephalic-hippocampal circuitry, including thalamic nuclei and mammillary bodies.
The loss of cholinergic cells in the basal forebrain region results in decreased cholinergic input to the hippocampus and the cortex and reduced choline acetyltransferase and acetylcholinesterase activities and function, as well as in acetylcholine receptor downregulation within these brain regions.
In this narrative review, we will focus on the neurochemical, neuroanatomical, and neuropsychological studies shedding light on the effects of thiamine deficiency in experimental models and in humans.
American Psychological Association (APA)
Nardone, Raffaele& Höller, Yvonne& Storti, Monica& Christova, Monica& Tezzon, Frediano& Golaszewski, Stefan…[et al.]. 2013. Thiamine Deficiency Induced Neurochemical, Neuroanatomical, and Neuropsychological Alterations: A Reappraisal. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032775
Modern Language Association (MLA)
Nardone, Raffaele…[et al.]. Thiamine Deficiency Induced Neurochemical, Neuroanatomical, and Neuropsychological Alterations: A Reappraisal. The Scientific World Journal No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1032775
American Medical Association (AMA)
Nardone, Raffaele& Höller, Yvonne& Storti, Monica& Christova, Monica& Tezzon, Frediano& Golaszewski, Stefan…[et al.]. Thiamine Deficiency Induced Neurochemical, Neuroanatomical, and Neuropsychological Alterations: A Reappraisal. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032775