Antioxidant, Antityrosinase, Anticholinesterase, and Nitric Oxide Inhibition Activities of Three Malaysian Macaranga Species
Joint Authors
Mazlan, Nor Aishah
Mediani, Ahmed
Abas, Faridah
Ahmad, Syahida
Khamis, Shamsul
Lajis, N. H.
Shaari, Khozirah
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The methanol extracts of three Macaranga species (M.
denticulata, M.
pruinosa, and M.
gigantea) were screened to evaluate their total phenolic contents and activities as cholinesterase inhibitors, nitric oxide (NO) production inhibitors, tyrosinase inhibitors, and antioxidants.
The bark of M.
denticulata showed the highest total phenolic content (2682 mg gallic acid equivalent (GAE)/100 g) and free radical scavenging activity (IC50 = 0.063 mg/mL).
All of the samples inhibited linoleic acid peroxidation by greater than 80%, with the leaves of M.
gigantea exhibiting the highest inhibition of 92.21%.
Most of the samples exhibited significant antioxidant potential.
The bark of M.
denticulata and the leaves of both M.
pruinosa and M.
gigantea exhibited greater than 50% tyrosinase inhibition, with the bark of M.
denticulata having the highest percentage of inhibition (68.7%).
The bark and leaves of M.
denticulata exhibited greater than 50% inhibition (73.82% and 54.50%, resp.) of the acetylcholinesterase enzyme (AChE), while none of the samples showed any significant inhibition of butyrylcholinesterase (BChE).
Only the bark of M.
denticulata and M.
gigantea displayed greater than 50% inhibition of nitric oxide production in cells (81.79% and 56.51%, resp.).
These bioactivities indicate that some Macaranga spp.
have therapeutic potential in medicinal research.
American Psychological Association (APA)
Mazlan, Nor Aishah& Mediani, Ahmed& Abas, Faridah& Ahmad, Syahida& Shaari, Khozirah& Khamis, Shamsul…[et al.]. 2013. Antioxidant, Antityrosinase, Anticholinesterase, and Nitric Oxide Inhibition Activities of Three Malaysian Macaranga Species. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032778
Modern Language Association (MLA)
Mazlan, Nor Aishah…[et al.]. Antioxidant, Antityrosinase, Anticholinesterase, and Nitric Oxide Inhibition Activities of Three Malaysian Macaranga Species. The Scientific World Journal No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1032778
American Medical Association (AMA)
Mazlan, Nor Aishah& Mediani, Ahmed& Abas, Faridah& Ahmad, Syahida& Shaari, Khozirah& Khamis, Shamsul…[et al.]. Antioxidant, Antityrosinase, Anticholinesterase, and Nitric Oxide Inhibition Activities of Three Malaysian Macaranga Species. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032778