The Effect of Anabolic Steroid Administration on Passive Stretching-Induced Expression of Mechano-Growth Factor in Skeletal Muscle
Joint Authors
Ikeda, Satoshi
Harada, Katsuhiro
Ohwatashi, Akihiko
Kamikawa, Yurie
Yoshida, Akira
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Stretching of skeletal muscle induces expression of the genes which encode myogenic transcription factors or muscle contractile proteins and results in muscle growth.
Anabolic steroids are reported to strengthen muscles.
We have previously studied the effects of muscle stretching on gene expression.
Here, we studied the effect of a combination of passive stretching and the administration of an anabolic steroid on mRNA expression of a muscle growth factor, insulin-like growth factor-I autocrine variant, or mechano-growth factor (MGF).
Methods.
Twelve 8-week-old male Wistar rats were used.
Metenolone was administered and passive repetitive dorsiflexion and plantar flexion of the ankle joint performed under deep anesthesia.
After 24 h, the gastrocnemius muscles were removed and the mRNA expression of insulin-like growth factor-I autocrine variant was measured using quantitative real-time polymerase chain reaction.
Results.
Repetitive stretching in combination with metenolone, but not stretching alone, significantly increased MGF mRNA expression.
Conclusion.
Anabolic steroids enhance the effect of passive stretching on MGF expression in skeletal muscle.
American Psychological Association (APA)
Ikeda, Satoshi& Kamikawa, Yurie& Ohwatashi, Akihiko& Harada, Katsuhiro& Yoshida, Akira. 2013. The Effect of Anabolic Steroid Administration on Passive Stretching-Induced Expression of Mechano-Growth Factor in Skeletal Muscle. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1032779
Modern Language Association (MLA)
Ikeda, Satoshi…[et al.]. The Effect of Anabolic Steroid Administration on Passive Stretching-Induced Expression of Mechano-Growth Factor in Skeletal Muscle. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1032779
American Medical Association (AMA)
Ikeda, Satoshi& Kamikawa, Yurie& Ohwatashi, Akihiko& Harada, Katsuhiro& Yoshida, Akira. The Effect of Anabolic Steroid Administration on Passive Stretching-Induced Expression of Mechano-Growth Factor in Skeletal Muscle. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1032779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032779