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The Effect of Mirtazapine on Cisplatin-Induced Oxidative Damage and Infertility in Rat Ovaries
Joint Authors
Altuner, Durdu
Gulaboglu, Mine
Yapca, Omer Erkan
Cetin, Nihal
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Cisplatin causes infertility due to ovarian toxicity.
The toxicity mechanism is unknown, but evidence suggests oxidative stress.
In this study, the effect of mirtazapine on cisplatin-induced infertility and oxidative stress in rats was investigated.
64 female rats were divided into 4 groups of 16.
Except for the controls that received physiologic saline only, all were administered with cisplatin (5 mg/kg i.p.) and mirtazapine (15 mg/kg p.o.) or mirtazapine (30 mg/kg p.o.) for 10 days.
After this period, six rats from each group were randomly selected, and malondialdehyde (MDA), myeloperoxidase (MPO), nitric oxide (NO), total gluthatione (tGSH), gluthatione peroxidase (GPx), superoxide dismutase (SOD), and 8-hydroxy-2 deoxyguanine (8-OH Gua) levels were measured in their ovarian tissues.
Reproductive functions of the remaining rats were examined for 6 months.
The MDA, MPO, NO groups and 8-OH Gua levels were higher in the cisplatin-treated groups than the controls, which was not observed in the mirtazapine and cisplatin groups.
GSH, GPx, and SOD levels were reduced by cisplatin, which was prevented by mirtazapine.
Cisplatin caused infertility by 70%.
The infertility rates were, respectively, 40% and 10% for the 15 and 30 mg/kg mirtazapine administered groups.
In conclusion, oxidative stress induced by cisplatin in the rat ovary tissue causes infertility in the female rats.
Mirtazapine reverses this in a dose-dependent manner.
American Psychological Association (APA)
Altuner, Durdu& Gulaboglu, Mine& Yapca, Omer Erkan& Cetin, Nihal. 2013. The Effect of Mirtazapine on Cisplatin-Induced Oxidative Damage and Infertility in Rat Ovaries. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1032790
Modern Language Association (MLA)
Altuner, Durdu…[et al.]. The Effect of Mirtazapine on Cisplatin-Induced Oxidative Damage and Infertility in Rat Ovaries. The Scientific World Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1032790
American Medical Association (AMA)
Altuner, Durdu& Gulaboglu, Mine& Yapca, Omer Erkan& Cetin, Nihal. The Effect of Mirtazapine on Cisplatin-Induced Oxidative Damage and Infertility in Rat Ovaries. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1032790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032790