Cognitive Intraindividual Variability and White Matter Integrity in Aging
Joint Authors
Mella, Nathalie
de Ribaupierre, Sandrine
Eagleson, Roy
de Ribaupierre, Anik
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-23
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The intraindividual variability (IIV) of cognitive performance has been shown to increase with aging.
While brain research has generally focused on mean performance, little is known about neural correlates of cognitive IIV.
Nevertheless, some studies suggest that IIV relates more strongly than mean level of performance to the quality of white matter (WM).
Our study aims to explore the relation between WM integrity and cognitive IIV by combining functional (fMRI) and structural (diffusion tensor imaging, DTI) imaging.
Twelve young adults (aged 18–30 years) and thirteen older adults (61–82 years) underwent a battery of neuropsychological tasks, along with fMRI and DTI imaging.
Their behavioral data were analyzed and correlated with the imaging data at WM regions of interest defined on the basis of (1) the fMRI-activated areas and (2) the Johns Hopkins University (JHU) WM tractography atlas.
For both methods, fractional anisotropy, along with the mean, radial, and axial diffusivity parameters, was computed.
In accord with previous studies, our results showed that the DTI parameters were more related to IIV than to mean performance.
Results also indicated that age differences in the DTI parameters were more pronounced in the regions activated primarily by young adults during a choice reaction-time task than in those also activated in older adults.
American Psychological Association (APA)
Mella, Nathalie& de Ribaupierre, Sandrine& Eagleson, Roy& de Ribaupierre, Anik. 2013. Cognitive Intraindividual Variability and White Matter Integrity in Aging. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-1032807
Modern Language Association (MLA)
Mella, Nathalie…[et al.]. Cognitive Intraindividual Variability and White Matter Integrity in Aging. The Scientific World Journal No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-1032807
American Medical Association (AMA)
Mella, Nathalie& de Ribaupierre, Sandrine& Eagleson, Roy& de Ribaupierre, Anik. Cognitive Intraindividual Variability and White Matter Integrity in Aging. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-1032807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032807