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The Effect of Reagents Mimicking Oxidative Stress on Fibrinogen Function
Joint Authors
Dyr, Jan E.
Štikarová, Jana
Kotlín, Roman
Riedel, Tomáš
Pimková, Kristýna
Chrastinová, Leona
Suttnar, Jiri
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Fibrinogen is one of the plasma proteins most susceptible to oxidative modification.
It has been suggested that modification of fibrinogen may cause thrombotic/bleeding complications associated with many pathophysiological states of organism.
We exposed fibrinogen molecules to three different modification reagents—malondialdehyde, sodium hypochlorite, and peroxynitrite—that are presented to various degrees in different stages of oxidative stress.
We studied the changes in fibrin network formation and platelet interactions with modified fibrinogens under flow conditions.
The fastest modification of fibrinogen was caused by hypochlorite.
Fibers from fibrinogen modified with either reagent were thinner in comparison with control fibers.
We found that platelet dynamic adhesion was significantly lower on fibrinogen modified with malondialdehyde and significantly higher on fibrinogen modified either with hypochlorite or peroxynitrite reflecting different prothrombotic/antithrombotic properties of oxidatively modified fibrinogens.
It seems that, in the complex reactions ongoing in living organisms at conditions of oxidation stress, hypochlorite modifies proteins (e.g., fibrinogen) faster and more preferentially than malondialdehyde.
It suggests that the prothrombotic effects of prior fibrinogen modifications may outweigh the antithrombotic effect of malondialdehyde-modified fibrinogen in real living systems.
American Psychological Association (APA)
Štikarová, Jana& Kotlín, Roman& Riedel, Tomáš& Suttnar, Jiri& Pimková, Kristýna& Chrastinová, Leona…[et al.]. 2013. The Effect of Reagents Mimicking Oxidative Stress on Fibrinogen Function. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032815
Modern Language Association (MLA)
Štikarová, Jana…[et al.]. The Effect of Reagents Mimicking Oxidative Stress on Fibrinogen Function. The Scientific World Journal No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1032815
American Medical Association (AMA)
Štikarová, Jana& Kotlín, Roman& Riedel, Tomáš& Suttnar, Jiri& Pimková, Kristýna& Chrastinová, Leona…[et al.]. The Effect of Reagents Mimicking Oxidative Stress on Fibrinogen Function. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032815