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Plasma Homocysteine Is Associated with Increased Oxidative Stress and Antioxidant Enzyme Activity in Welders
Joint Authors
Huang, Yi-Chia
Huang, Shih-Chien
Liu, Hung-Hsin
Shih, Tung-Sheng
Huang, Hsin-Ru
Lee, Lien-Hsiung
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The purpose of this study was to examine the association of vitamin B6 status and plasma homocysteine with oxidative stress and antioxidant capacities in welders.
Workers were divided into either the welding exposure group (n=57) or the nonexposure controls (n=42) based on whether they were employed as welders.
There were no significant differences in vitamin B6 status and plasma homocysteine concentration between the welding exposure group and the nonexposure controls.
The welding exposure group had significantly higher levels of oxidized low-density lipoprotein cholesterol and lower erythrocyte glutathione concentration and superoxide dismutase (SOD) activities when compared to nonexposure controls.
Plasma pyridoxal 5′-phosphate concentration did not correlate with oxidative stress indicators or antioxidant capacities in either group.
However, plasma homocysteine significantly correlated with total antioxidant capacity (TAC) (partial rs=-0.34, P<0.05) and erythrocyte SOD activities (partial rs=0.29, P<0.05) after adjusting for potential confounders in the welding exposure group.
In the welding exposure group, adequate vitamin B6 status was not associated with oxidative stress or antioxidant capacities.
However, elevated plasma homocysteine seemed to be a major contributing factor to antioxidant capacities (TAC and erythrocyte SOD activities) in welders.
American Psychological Association (APA)
Liu, Hung-Hsin& Shih, Tung-Sheng& Huang, Hsin-Ru& Huang, Shih-Chien& Lee, Lien-Hsiung& Huang, Yi-Chia. 2013. Plasma Homocysteine Is Associated with Increased Oxidative Stress and Antioxidant Enzyme Activity in Welders. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032832
Modern Language Association (MLA)
Liu, Hung-Hsin…[et al.]. Plasma Homocysteine Is Associated with Increased Oxidative Stress and Antioxidant Enzyme Activity in Welders. The Scientific World Journal No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1032832
American Medical Association (AMA)
Liu, Hung-Hsin& Shih, Tung-Sheng& Huang, Hsin-Ru& Huang, Shih-Chien& Lee, Lien-Hsiung& Huang, Yi-Chia. Plasma Homocysteine Is Associated with Increased Oxidative Stress and Antioxidant Enzyme Activity in Welders. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032832