Biological and Demographic Profile of Meningiomas in a Cohort of Egyptian Patients: Impact on Tumor Recurrence
Joint Authors
Abdelzaher, Eman
El Deeb, Nevine M. F.
Gowil, Ahmed G.
Yehya, Ahmed
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Objective.
This work was designed to study the biological and demographic characteristics of meningiomas and their impact on tumor recurrence in Egyptian patients.
Material and Methods.
A cohort of 265 Egyptian patients with meningioma was studied.
Immunohistochemistry for VEGF, Ki67, PR, CD20, and CD3 was performed.
Statistical analysis was used to detect independent predictors of recurrence.
Results.
Adults represented 98.9% of cases, with female preponderance (M : F ratio = 1 : 2.4).
Histologically, 78.10% of cases were grade I, 19.20% were grade II, and 2.60% were grade III.
Transitional variant was the most common (43.40%).
VEGF expression (38.50% of cases) correlated positively with perifocal edema, tumor size, and proliferative index (PI).
PR expression (64.5% of cases) correlated inversely with the PI (mean 3.75).
Lymphocytic aggregates were detected in 7.20% of cases, with a mean CD20 : CD3 ratio of 1 : 10.1.
In a multivariate analysis, only tumor size, PR expression and necrosis predicted recurrence independently.
Using ROC curve, size was the best predictor of tumor recurrence with a cut-off point of >6 cm and an excellent negative predictive value (97.6%).
Conclusions.
Meningiomas in our region showed some distinctive clinicopathological and demographic criteria.
Tumor size was found to be the best recurrence predictor factor of meningioma.
American Psychological Association (APA)
Abdelzaher, Eman& El Deeb, Nevine M. F.& Gowil, Ahmed G.& Yehya, Ahmed. 2013. Biological and Demographic Profile of Meningiomas in a Cohort of Egyptian Patients: Impact on Tumor Recurrence. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032837
Modern Language Association (MLA)
Abdelzaher, Eman…[et al.]. Biological and Demographic Profile of Meningiomas in a Cohort of Egyptian Patients: Impact on Tumor Recurrence. The Scientific World Journal No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1032837
American Medical Association (AMA)
Abdelzaher, Eman& El Deeb, Nevine M. F.& Gowil, Ahmed G.& Yehya, Ahmed. Biological and Demographic Profile of Meningiomas in a Cohort of Egyptian Patients: Impact on Tumor Recurrence. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032837