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Expression and Significance of MicroRNA-183 in Hepatocellular Carcinoma
Joint Authors
Guo, Hua
Gao, Ying-tang
Jing, Li
Liu, Tong
Zhai, Dao-kuan
Du, Zhi
Liang, Zenghui
Shi, Wenxia
Li, Shilei
Wang, Yajie
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Objective.
In our previous study, we found that some miRNAs were deregulated in hepatocellular carcinoma (HCC), including miR-183.
However, the expression of miR-183 in the progression of benign liver diseases to HCC and its correlation with clinicopathologic factors remain undefined.
Methods.
MiR-183 expression was measured in normal controls (NC) (n=21), chronic viral hepatitis B or C (CH) tissues (n=10), liver cirrhosis (LC) tissues (n=18), HCC tissues (n=92), and adjacent nontumor tissues (NT) (n=92) by quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR).
Results.
The expression levels of miR-183 were significantly higher in HCC than in NT, LC, CH, and NL (P=0.001, P<0.001, P=0.011, P<0.001, resp.).
The upregulated miR-183 in HCC was correlated with TNM stage (P=0.042) and cirrhosis (P=0.025).
The Kaplan-Meier survival analysis showed that miR-183 expression was not associated with the survival of HCC patients.
However, miR-183 yielded an area under the curve (AUC) of 0.808 with 59.8% sensitivity and 91.8% specificity in discriminating HCC from benign liver diseases (CH and LC) or NC.
Conclusions.
The upregulated miR-183 may associate with onset and progression of HCC, but not with the patient survival.
A further research is needed to determine the potential of miR-183 as biomarker for HCC.
American Psychological Association (APA)
Liang, Zenghui& Gao, Ying-tang& Shi, Wenxia& Zhai, Dao-kuan& Li, Shilei& Jing, Li…[et al.]. 2013. Expression and Significance of MicroRNA-183 in Hepatocellular Carcinoma. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1032847
Modern Language Association (MLA)
Liang, Zenghui…[et al.]. Expression and Significance of MicroRNA-183 in Hepatocellular Carcinoma. The Scientific World Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1032847
American Medical Association (AMA)
Liang, Zenghui& Gao, Ying-tang& Shi, Wenxia& Zhai, Dao-kuan& Li, Shilei& Jing, Li…[et al.]. Expression and Significance of MicroRNA-183 in Hepatocellular Carcinoma. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1032847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032847