Absorption and Metabolism Characteristics of Rutin in Caco-2 Cells
Joint Authors
Zhang, Xiaofang
Song, Jinhui
Shi, Xiaopeng
Miao, Shan
Li, Yan
Wen, Ai-dong
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The intestinal absorption and metabolism characteristics of the potentially beneficial polyphenol rutin were studied by measuring the intracellular accumulation and transport of rutin into Caco-2 cells with the sensitive and reliable analytical method of HPLC-coupled tandem mass spectrometry.
Rutin and glucuronidated rutin were absorbed differently by the basolateral and apical membranes, and rutin showed differential permeability through the apical and basolateral sides.
Approximately 33% of the rutin was metabolized to glucuronidated rutin, and the intracellular concentration of glucuronidated rutin was much lower than that of parent rutin.
P-glycoprotein and multidrug-resistant proteins 2 and 3 were involved in the transmembrane transport and intracellular accumulation of rutin by Caco-2 cells.
These results suggest that a specific transport system mediates rutin movement across the apical membrane in Caco-2 cells and that metabolic enzymes are important for this process.
American Psychological Association (APA)
Zhang, Xiaofang& Song, Jinhui& Shi, Xiaopeng& Miao, Shan& Li, Yan& Wen, Ai-dong. 2013. Absorption and Metabolism Characteristics of Rutin in Caco-2 Cells. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032848
Modern Language Association (MLA)
Zhang, Xiaofang…[et al.]. Absorption and Metabolism Characteristics of Rutin in Caco-2 Cells. The Scientific World Journal No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1032848
American Medical Association (AMA)
Zhang, Xiaofang& Song, Jinhui& Shi, Xiaopeng& Miao, Shan& Li, Yan& Wen, Ai-dong. Absorption and Metabolism Characteristics of Rutin in Caco-2 Cells. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1032848
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032848