New Tools in HCV Diagnosis, in Light of the Enhanced Awareness and the New Drugs for Treatment: SMARTube and Stimmunology
Joint Authors
Gorodin, Svetlana
Unal, Serhat
Wang, Youchun
Mikhaylov, Mikhail I.
Bigbulatova, Ludmila
Jehuda-Cohen, Tamar
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
With improved HCV therapy, challenges regarding HCV diagnosis, such as seronegative window period, false positive readings, and differentiation between recent, chronic, and resolved infections, are of increasing importance.
To address these challenges an innovative device—SMARTube HIV & HCV—was used.
Blood samples were tested for anti-HCV antibodies before and after incubation in the SMARTube, which promotes the in vitro stimulation of in vivo HCV primed lymphocytes, thus enhancing levels of anti-HCV antibodies.
Comparing antibody levels, in concordant samples before and after SMARTube, yielded the Stimulation Index (SI).
Among 5888 fresh blood samples, from various populations and regions worldwide, 641 were seropositive using plasma, while SMARTube processing (yielding enriched plasma, termed SMARTplasma) enabled diagnosis of 10 additional carriers in high-risk cohorts, that is, earlier detection.
Using SMARTplasma eliminated all false positive results, using the current assays.
In addition we show that SI calculation may serve as an important tool for differentiating between those who recently seroconverted, carriers of long-term infection, and those who have cleared the virus.
SMARTube and the SI could lead to better, more informative diagnosis of HCV infections and play an important role in changing the way we treat both the infected individuals and the epidemic as a whole.
American Psychological Association (APA)
Gorodin, Svetlana& Unal, Serhat& Wang, Youchun& Mikhaylov, Mikhail I.& Bigbulatova, Ludmila& Jehuda-Cohen, Tamar. 2013. New Tools in HCV Diagnosis, in Light of the Enhanced Awareness and the New Drugs for Treatment: SMARTube and Stimmunology. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1032861
Modern Language Association (MLA)
Gorodin, Svetlana…[et al.]. New Tools in HCV Diagnosis, in Light of the Enhanced Awareness and the New Drugs for Treatment: SMARTube and Stimmunology. The Scientific World Journal No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1032861
American Medical Association (AMA)
Gorodin, Svetlana& Unal, Serhat& Wang, Youchun& Mikhaylov, Mikhail I.& Bigbulatova, Ludmila& Jehuda-Cohen, Tamar. New Tools in HCV Diagnosis, in Light of the Enhanced Awareness and the New Drugs for Treatment: SMARTube and Stimmunology. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1032861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032861