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Lack of Significant Association between PlasmaSerum miR-221 Expression and Poor Survival of Carcinoma: A Meta-Analysis
Joint Authors
Dang, Yiwu
Rong, Minhua
Chen, Gang
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background.
MicroRNAs (miRNAs) exhibit altered expression levels in cancers, and they may play a potential role as diagnostic and prognostic biomarkers of cancers.
The aim of this meta-analysis was to summarize recent advances in miR-221 involvement in a variety of carcinomas and derive a more precise estimation of the relationship between circulating miR-221 level and survival of cancer patients.
Methods.
We searched online PubMed, EMBASE, and Cochrane Library up to August 2013 to identify relevant studies.
Data were collected from studies comparing survival in patients with various carcinomas with higher miR-221 expression to those with lower levels.
Pooled hazard ratios (HRs) of miR-221 for survival were calculated.
Results.
There were 4 studies included in the meta-analysis.
The results of meta-analysis suggested that no significant difference in poor overall survival between miR-221 high and low groups (OR = 0.94, 95%, CI = 0.47–1.87, Z=0.17, and P=0.863).
Conclusions.
The current meta-analysis showed the equivalence of high and low plasma/serum miR-221 expression for carcinomas in terms of survival.
American Psychological Association (APA)
Rong, Minhua& Dang, Yiwu& Chen, Gang. 2013. Lack of Significant Association between PlasmaSerum miR-221 Expression and Poor Survival of Carcinoma: A Meta-Analysis. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1032864
Modern Language Association (MLA)
Rong, Minhua…[et al.]. Lack of Significant Association between PlasmaSerum miR-221 Expression and Poor Survival of Carcinoma: A Meta-Analysis. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1032864
American Medical Association (AMA)
Rong, Minhua& Dang, Yiwu& Chen, Gang. Lack of Significant Association between PlasmaSerum miR-221 Expression and Poor Survival of Carcinoma: A Meta-Analysis. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1032864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032864