Ineffective Erythropoiesis in β-Thalassemia
Joint Authors
Ribeil, Jean-Antoine
Arlet, Jean-Benoit
Dussiot, Michael
Cruz Moura, Ivan
Courtois, Geneviève
Hermine, Olivier
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
In humans, β-thalassemia dyserythropoiesis is characterized by expansion of early erythroid precursors and erythroid progenitors and then ineffective erythropoiesis.
This ineffective erythropoiesis is defined as a suboptimal production of mature erythrocytes originating from a proliferating pool of immature erythroblasts.
It is characterized by (1) accelerated erythroid differentiation, (2) maturation blockade at the polychromatophilic stage, and (3) death of erythroid precursors.
Despite extensive knowledge of molecular defects causing β-thalassemia, less is known about the mechanisms responsible for ineffective erythropoiesis.
In this paper, we will focus on the underlying mechanisms leading to premature death of thalassemic erythroid precursors in the bone marrow.
American Psychological Association (APA)
Ribeil, Jean-Antoine& Arlet, Jean-Benoit& Dussiot, Michael& Cruz Moura, Ivan& Courtois, Geneviève& Hermine, Olivier. 2013. Ineffective Erythropoiesis in β-Thalassemia. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1032865
Modern Language Association (MLA)
Ribeil, Jean-Antoine…[et al.]. Ineffective Erythropoiesis in β-Thalassemia. The Scientific World Journal No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1032865
American Medical Association (AMA)
Ribeil, Jean-Antoine& Arlet, Jean-Benoit& Dussiot, Michael& Cruz Moura, Ivan& Courtois, Geneviève& Hermine, Olivier. Ineffective Erythropoiesis in β-Thalassemia. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1032865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032865