The Evolutionary Relationship between Microbial Rhodopsins and Metazoan Rhodopsins
Joint Authors
Shen, Libing
Chen, Chao
Zheng, Hongxiang
Jin, Li
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Rhodopsins are photoreceptive proteins with seven-transmembrane alpha-helices and a covalently bound retinal.
Based on their protein sequences, rhodopsins can be classified into microbial rhodopsins and metazoan rhodopsins.
Because there is no clearly detectable sequence identity between these two groups, their evolutionary relationship was difficult to decide.
Through ancestral state inference, we found that microbial rhodopsins and metazoan rhodopsins are divergently related in their seven-transmembrane domains.
Our result proposes that they are homologous proteins and metazoan rhodopsins originated from microbial rhodopsins.
Structure alignment shows that microbial rhodopsins and metazoan rhodopsins share a remarkable structural homology while the position of retinal-binding lysine is different between them.
It suggests that the function of photoreception was once lost during the evolution of rhodopsin genes.
This result explains why there is no clearly detectable sequence similarity between the two rhodopsin groups: after losing the photoreception function, rhodopsin gene was freed from the functional constraint and the process of divergence could quickly change its original sequence beyond recognition.
American Psychological Association (APA)
Shen, Libing& Chen, Chao& Zheng, Hongxiang& Jin, Li. 2013. The Evolutionary Relationship between Microbial Rhodopsins and Metazoan Rhodopsins. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1032920
Modern Language Association (MLA)
Shen, Libing…[et al.]. The Evolutionary Relationship between Microbial Rhodopsins and Metazoan Rhodopsins. The Scientific World Journal No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1032920
American Medical Association (AMA)
Shen, Libing& Chen, Chao& Zheng, Hongxiang& Jin, Li. The Evolutionary Relationship between Microbial Rhodopsins and Metazoan Rhodopsins. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1032920
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032920