Goblet Cells and Mucin Related Gene Expression in Mice Infected with Eimeria papillata
Joint Authors
Dkhil, Muhammad A.
Delic, Denis
al-Quraishy, Salih
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Coccidiosis causes considerable economic loss in the poultry industry.
The current study aimed to investigate the response of goblet cells as well as the induced tissue damage during Eimeria papillata infection.
Mice were infected with sporulated E.
papillata oocytes.
On day 5 postinfection, the fecal output was determined.
Also, the jejunum was prepared for the histological, histochemical, and molecular studies.
Our results revealed that the intestinal coccidian infection with E.
papillata induced a marked goblet cell hypoplasia and depleted mucus secretion.
Also, the infection was able to alter the jejunal architecture and increased the apoptotic cells inside the villi.
In addition, the real-time PCR results indicated that the inflammatory cytokines: TNF-α, iNOS, IFN-γ, and IL-1β, were significantly upregulated.
In contrast, the mRNA expression patterns of IL-6 in response to E.
papillata infection did not differ significantly between control and infected mice.
Moreover, the mRNA expression of TLR4 was significantly upregulated, whereas the expression of MUC2 is significantly downregulated upon infection.
Further studies are required to understand the regulatory mechanisms of goblet cells related genes.
American Psychological Association (APA)
Dkhil, Muhammad A.& Delic, Denis& al-Quraishy, Salih. 2013. Goblet Cells and Mucin Related Gene Expression in Mice Infected with Eimeria papillata. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1032926
Modern Language Association (MLA)
Dkhil, Muhammad A.…[et al.]. Goblet Cells and Mucin Related Gene Expression in Mice Infected with Eimeria papillata. The Scientific World Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1032926
American Medical Association (AMA)
Dkhil, Muhammad A.& Delic, Denis& al-Quraishy, Salih. Goblet Cells and Mucin Related Gene Expression in Mice Infected with Eimeria papillata. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1032926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032926