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Transient Hemodynamic Changes upon Changing a BCPA into a TCPC in Staged Fontan Operation: A Computational Model Study
Joint Authors
Senzaki, Hideaki
Liang, Fuyou
Yin, Zhaofang
Fan, Yuqi
Sughimoto, Koichi
Liu, Hao
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The clinical benefits of the Fontan operation in treating single-ventricle defects have been well documented.
However, perioperative mortality or morbidity remains a critical problem.
The purpose of the present study was to identify the cardiovascular factors that dominate the transient hemodynamic changes upon the change of a bidirectional cavopulmonary (Glenn) anastomosis (BCPA) into a total cavopulmonary connection (TCPC).
For this purpose, two computational models were constructed to represent, respectively, a single-ventricle circulation with a BCPA and that with a TCPC.
A series of model-based simulations were carried out to quantify the perioperative hemodynamic changes under various cardiovascular conditions.
Obtained results indicated that the presence of a low pulmonary vascular resistance and/or a low lower-body vascular resistance is beneficial to the increase in transpulmonary flow upon the BCPA to TCPC change.
Moreover, it was found that ventricular diastolic dysfunction and mitral valve regurgitation, despite being well-known risk factors for poor postoperative outcomes, do not cause a considerable perioperative reduction in transpulmonary flow.
The findings may help physicians to assess the perioperative risk of the TCPC surgery based on preoperative measurement of cardiovascular function.
American Psychological Association (APA)
Liang, Fuyou& Senzaki, Hideaki& Yin, Zhaofang& Fan, Yuqi& Sughimoto, Koichi& Liu, Hao. 2013. Transient Hemodynamic Changes upon Changing a BCPA into a TCPC in Staged Fontan Operation: A Computational Model Study. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1032977
Modern Language Association (MLA)
Liang, Fuyou…[et al.]. Transient Hemodynamic Changes upon Changing a BCPA into a TCPC in Staged Fontan Operation: A Computational Model Study. The Scientific World Journal No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1032977
American Medical Association (AMA)
Liang, Fuyou& Senzaki, Hideaki& Yin, Zhaofang& Fan, Yuqi& Sughimoto, Koichi& Liu, Hao. Transient Hemodynamic Changes upon Changing a BCPA into a TCPC in Staged Fontan Operation: A Computational Model Study. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1032977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032977