Glutathione Redox System in β-ThalassemiaHb E Patients
Joint Authors
Kalpravidh, Ruchaneekorn W.
Tangjaidee, Thongchai
Hatairaktham, Suneerat
Charoensakdi, Ratiya
Panichkul, Narumol
Siritanaratkul, Noppadol
Fucharoen, Suthat
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
β-thalassemia/Hb E is known to cause oxidative stress induced by iron overload.
The glutathione system is the major endogenous antioxidant that protects animal cells from oxidative damage.
This study aimed to determine the effect of disease state and splenectomy on redox status expressed by whole blood glutathione (GSH)/glutathione disulfide (GSSG) and also to evaluate glutathione-related responses to oxidation in β-thalassemia/Hb E patients.
Twenty-seven normal subjects and 25 β-thalassemia/Hb E patients were recruited and blood was collected.
The GSH/GSSG ratio, activities of glutathione-related enzymes, hematological parameters, and serum ferritin levels were determined in individuals.
Patients had high iron-induced oxidative stress, shown as significantly increased serum ferritin, a decreased GSH/GSSG ratio, and increased activities of glutathione-related enzymes.
Splenectomy increased serum ferritin levels and decreased GSH levels concomitant with unchanged glutathione-related enzyme activities.
The redox ratio had a positive correlation with hemoglobin levels and negative correlation with levels of serum ferritin.
The glutathione system may be the body’s first-line defense used against oxidative stress and to maintain redox homeostasis in thalassemic patients based on the significant correlations between the GSH/GSSH ratio and degree of anemia or body iron stores.
American Psychological Association (APA)
Kalpravidh, Ruchaneekorn W.& Tangjaidee, Thongchai& Hatairaktham, Suneerat& Charoensakdi, Ratiya& Panichkul, Narumol& Siritanaratkul, Noppadol…[et al.]. 2013. Glutathione Redox System in β-ThalassemiaHb E Patients. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1033046
Modern Language Association (MLA)
Kalpravidh, Ruchaneekorn W.…[et al.]. Glutathione Redox System in β-ThalassemiaHb E Patients. The Scientific World Journal No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1033046
American Medical Association (AMA)
Kalpravidh, Ruchaneekorn W.& Tangjaidee, Thongchai& Hatairaktham, Suneerat& Charoensakdi, Ratiya& Panichkul, Narumol& Siritanaratkul, Noppadol…[et al.]. Glutathione Redox System in β-ThalassemiaHb E Patients. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1033046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033046