Denervation as a Common Mechanism Underlying Different Pulmonary Vein Isolation Strategies for Paroxysmal Atrial Fibrillation: Evidenced by Heart Rate Variability after Ablation

Joint Authors

Yang, Y.
Wang, Kejing
Chang, Dong
Chu, Zhenliang
Gao, Lianjun
Zhang, Shulong
Xia, Yunlong
Dong, Yingxue
Yin, Xiaomeng
Cong, Peixin
Jia, Jingjing

Source

The Scientific World Journal

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-08-24

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine
Information Technology and Computer Science

Abstract EN

Backgrounds.

Segmental and circumferential pulmonary vein isolations (SPVI and CPVI) have been demonstrated to be effective therapies for paroxysmal atrial fibrillation (PAF).

PVI is well established as the endpoint of different ablation techniques, whereas it may not completely account for the long-term success.

Methods.

181 drug-refractory symptomatic PAF patients were referred for segmental or circumferential PVI (SPVI = 67; CPVI = 114).

Heart rate variability (HRV) was assessed before and after the final ablation.

Results.

After following up for 62.23±12.75 months, patients underwent 1.41±0.68 procedures in average, and the success rates in SPVI and CPVI groups were comparable.

119 patients were free from AF recurrence (SPVI-S, n=43; CPVI-S, n=76).

56 patients had recurrent episodes (SPVI-R, n=21; CPVI-R, n=35).

Either ablation technique decreased HRV significantly.

Postablation SDNN and rMSSD were significantly lower in SPVI-S and CPVI-S subgroups than in SPVI-R and CPVI-R subgroups (SPVI-S versus SPVI-R: SDNN 91.8±32.6 versus 111.5±36.2 ms, rMSSD 47.4±32.3 versus 55.2±35.2 ms; CPVI-S versus CPVI-R: SDNN 83.0±35.6 versus 101.0±40.7 ms, rMSSD 41.1±22.9 versus 59.2±44.8 ms; all P<0.05).

Attenuation of SDNN and rMSSD remained for 12 months in SPVI-S and CPVI-S subgroups, whereas it recovered earlier in SPVI-R and CPVI-R subgroups.

Multivariate logistic regression analysis identified SDNN as the only predictor of long-term success.

Conclusions.

Beyond PVI, denervation may be a common mechanism underlying different ablation strategies for PAF.

American Psychological Association (APA)

Wang, Kejing& Chang, Dong& Chu, Zhenliang& Yang, Y.& Gao, Lianjun& Zhang, Shulong…[et al.]. 2013. Denervation as a Common Mechanism Underlying Different Pulmonary Vein Isolation Strategies for Paroxysmal Atrial Fibrillation: Evidenced by Heart Rate Variability after Ablation. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1033063

Modern Language Association (MLA)

Wang, Kejing…[et al.]. Denervation as a Common Mechanism Underlying Different Pulmonary Vein Isolation Strategies for Paroxysmal Atrial Fibrillation: Evidenced by Heart Rate Variability after Ablation. The Scientific World Journal No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1033063

American Medical Association (AMA)

Wang, Kejing& Chang, Dong& Chu, Zhenliang& Yang, Y.& Gao, Lianjun& Zhang, Shulong…[et al.]. Denervation as a Common Mechanism Underlying Different Pulmonary Vein Isolation Strategies for Paroxysmal Atrial Fibrillation: Evidenced by Heart Rate Variability after Ablation. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1033063

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1033063