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The Influence of Storage Temperature on the Antibiotic Release of Vancomycin-Loaded Polymethylmethacrylate
Joint Authors
Chen, Dave W.
Chang, Yuhan
Hsieh, Pang-Hsin
Ueng, Steve W. N.
Lee, Mel S.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-21
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Periprosthetic joint infection is devastating and increases medical expenditure and socioeconomic burden.
Antibiotic-loaded cement spacer is useful in the interim period before the reimplantation surgery.
Prefabricated antibiotic-loaded cement spacers can decrease operation time but have been limitedly used clinically.
In the literature, there is no clear recommendation on the storage temperature for the prefabricated cement spacers.
We used an in vitro model to analyze whether the storage temperature at 25°C, 4°C, or −20°C for 2 weeks or 3 months could affect the release of vancomycin from the cement.
We found that the storage temperature and time had no significant effects on the pattern and amount of vancomycin release.
The patterns of vancomycin release from the cement stored at different temperatures were similar with an abrupt release in the first 3 days and steadily declined in the following period.
This study provides a preliminary result to justify the storage of fabricating antibiotic-loaded cement spacer sterilely packed at room temperature.
Further studies to examine the effects of storage temperature on the mechanical strength and the release pattern of other antibiotics should be done to provide more evidence to support the clinical use of prefabricated ready-to-use antibiotic-loaded cement spacer.
American Psychological Association (APA)
Chen, Dave W.& Chang, Yuhan& Hsieh, Pang-Hsin& Ueng, Steve W. N.& Lee, Mel S.. 2013. The Influence of Storage Temperature on the Antibiotic Release of Vancomycin-Loaded Polymethylmethacrylate. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1033069
Modern Language Association (MLA)
Chen, Dave W.…[et al.]. The Influence of Storage Temperature on the Antibiotic Release of Vancomycin-Loaded Polymethylmethacrylate. The Scientific World Journal No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-1033069
American Medical Association (AMA)
Chen, Dave W.& Chang, Yuhan& Hsieh, Pang-Hsin& Ueng, Steve W. N.& Lee, Mel S.. The Influence of Storage Temperature on the Antibiotic Release of Vancomycin-Loaded Polymethylmethacrylate. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1033069
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033069