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Reestablishment of Ischemia-Reperfusion Liver Injury by N-Acetylcysteine Administration prior to a Preconditioning Iron Protocol
Joint Authors
Vargas, Romina
Castillo, Valentina
Cádiz, Nicolás
Bastías, Daniela
Román, Sebastián
Tapia, Gladys
Fernández, Virginia
Videla, Luis A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The role of iron (Fe)-induced prooxidant status in Fe preconditioning against ischemia (1 h)-reperfusion (20 h) induced liver injury was assessed using N-acetylcysteine (NAC) (1 g/kg) before Fe (50 mg/kg), given to male Sprague Dawley rats on alternate days during 10 days.
IR significantly increased serum aspartate transaminase (AST) and alanine transaminase (ALT) levels, with drastic changes in liver histology, hepatic glutathione depletion, and nuclear factor-κB (NF-κB) p65 diminution (P<0.05) (ELISA).
Fe-induced liver oxidative stress, as evidenced by higher protein carbonyl/glutathione content ratios (P<0.05) at days 11 and 12 after treatment, was abolished by NAC.
Under these conditions, short-term Fe administration exerted significant protection against IR liver injury, as shown by 85% and 60% decreases in IR-induced serum AST and ALT (P<0.05), respectively, and normalization of hepatic histology, glutathione levels, and NF-κB activation, changes that were suppressed by NAC administration prior to Fe.
Results of this study indicate that NAC administration prior to an iron protocol reestablishes IR liver injury, supporting the role of Fe-induced transient oxidative stress in hepatoprotection and its potential clinical application.
American Psychological Association (APA)
Fernández, Virginia& Vargas, Romina& Castillo, Valentina& Cádiz, Nicolás& Bastías, Daniela& Román, Sebastián…[et al.]. 2013. Reestablishment of Ischemia-Reperfusion Liver Injury by N-Acetylcysteine Administration prior to a Preconditioning Iron Protocol. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1033106
Modern Language Association (MLA)
Fernández, Virginia…[et al.]. Reestablishment of Ischemia-Reperfusion Liver Injury by N-Acetylcysteine Administration prior to a Preconditioning Iron Protocol. The Scientific World Journal No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1033106
American Medical Association (AMA)
Fernández, Virginia& Vargas, Romina& Castillo, Valentina& Cádiz, Nicolás& Bastías, Daniela& Román, Sebastián…[et al.]. Reestablishment of Ischemia-Reperfusion Liver Injury by N-Acetylcysteine Administration prior to a Preconditioning Iron Protocol. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1033106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033106