A Comparative Genomic Study in Schizophrenic and in Bipolar Disorder Patients, Based on Microarray Expression Profiling Meta-Analysis
Joint Authors
Chatziioannou, Aristotelis
Logotheti, Marianthi
Venizelos, Nikolaos
Kolisis, Fragiskos N.
Papadodima, Olga
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Schizophrenia affecting almost 1% and bipolar disorder affecting almost 3%–5% of the global population constitute two severe mental disorders.
The catecholaminergic and the serotonergic pathways have been proved to play an important role in the development of schizophrenia, bipolar disorder, and other related psychiatric disorders.
The aim of the study was to perform and interpret the results of a comparative genomic profiling study in schizophrenic patients as well as in healthy controls and in patients with bipolar disorder and try to relate and integrate our results with an aberrant amino acid transport through cell membranes.
In particular we have focused on genes and mechanisms involved in amino acid transport through cell membranes from whole genome expression profiling data.
We performed bioinformatic analysis on raw data derived from four different published studies.
In two studies postmortem samples from prefrontal cortices, derived from patients with bipolar disorder, schizophrenia, and control subjects, have been used.
In another study we used samples from postmortem orbitofrontal cortex of bipolar subjects while the final study was performed based on raw data from a gene expression profiling dataset in the postmortem superior temporal cortex of schizophrenics.
The data were downloaded from NCBI's GEO datasets.
American Psychological Association (APA)
Logotheti, Marianthi& Papadodima, Olga& Venizelos, Nikolaos& Chatziioannou, Aristotelis& Kolisis, Fragiskos N.. 2013. A Comparative Genomic Study in Schizophrenic and in Bipolar Disorder Patients, Based on Microarray Expression Profiling Meta-Analysis. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1033193
Modern Language Association (MLA)
Logotheti, Marianthi…[et al.]. A Comparative Genomic Study in Schizophrenic and in Bipolar Disorder Patients, Based on Microarray Expression Profiling Meta-Analysis. The Scientific World Journal No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1033193
American Medical Association (AMA)
Logotheti, Marianthi& Papadodima, Olga& Venizelos, Nikolaos& Chatziioannou, Aristotelis& Kolisis, Fragiskos N.. A Comparative Genomic Study in Schizophrenic and in Bipolar Disorder Patients, Based on Microarray Expression Profiling Meta-Analysis. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1033193
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033193