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Antipsychotic-Like Effect of Trimetazidine in a Rodent Model
Joint Authors
Taskiran, Dilek
Erbaş, Oytun
Akseki, Hüseyin Serdar
Eliküçük, Betül
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Trimetazidine (TMZ) has been used as an anti-ischemic agent for angina pectoris, chorioretinal disturbances, and vertigo.
Also, it can induce extrapyramidal type adverse reaction such as parkinsonism, gait disorder, and tremor via blockade of D2 receptors.
In the present study, we evaluated the effect of TMZ on novelty-induced rearing behavior and apomorphine-induced stereotypy behavior in male rats.
Four groups of rat (n=7) were administrated with TMZ (10 and 20 mg/kg, i.p.), chlorpromazine (1 mg/kg, i.p.), or isotonic saline.
One hour later, apomorphine (2 mg/kg, s.c.) was administrated to each rat.
Our results showed that both doses of TMZ significantly decreased the rearing behavior in rats, whereas the decrease with chlorpromazine was higher.
TMZ also decreased the stereotypy scores in a dose-dependent manner.
We concluded that TMZ has beneficial effects on rearing behavior and stereotypy, which are accepted to be indicators of antipsychotic effect.
Taken together, with its antioxidative and cytoprotective properties, TMZ is worthy of being investigated for its anti-psychotic effects as a primary or an adjunctive drug.
American Psychological Association (APA)
Erbaş, Oytun& Akseki, Hüseyin Serdar& Eliküçük, Betül& Taskiran, Dilek. 2013. Antipsychotic-Like Effect of Trimetazidine in a Rodent Model. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1033194
Modern Language Association (MLA)
Erbaş, Oytun…[et al.]. Antipsychotic-Like Effect of Trimetazidine in a Rodent Model. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1033194
American Medical Association (AMA)
Erbaş, Oytun& Akseki, Hüseyin Serdar& Eliküçük, Betül& Taskiran, Dilek. Antipsychotic-Like Effect of Trimetazidine in a Rodent Model. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1033194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033194