Oncogene- and Oxidative Stress-Induced Cellular Senescence Shows Distinct Expression Patterns of Proinflammatory Cytokines in Vascular Endothelial Cells
Joint Authors
Suzuki, Etsu
Takahashi, Masao
Oba, Shigeyoshi
Nishimatsu, Hiroaki
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Senescent cells are metabolically active and produce a variety of proinflammatory cytokines.
It was previously reported that atherosclerotic plaques contain senescent cells, suggesting that senescence may contribute to the progression of atherosclerosis.
In this study, we induced cellular senescence in vascular endothelial cells (VECs) using hydrogen peroxide (H2O2) or an adenovirus that expresses a constitutively active mutant of Ras (AdRas12V) and studied the expression of cytokines.
Both H2O2 treatment and AdRas12V infection induced senescence in VECs, as assessed by senescence-associated β-Gal activity and the expression of proteins such as p53 and p21CIP1.
In addition, both treatments induced the expression of a variety of cytokines, including interleukin-1β (IL-1β) and nerve growth factor (NGF).
AdRas12V infection induced IL-1β expression more significantly than H2O2 treatment, whereas both treatments induced comparable mRNA and protein expression levels of NGF.
These results suggest that senescent cells express different patterns of proinflammatory cytokines, depending on the trigger that induced senescence.
It is therefore possible that senescent cells can differentially induce inflammation in the surrounding tissues, depending on the cause of senescence.
American Psychological Association (APA)
Suzuki, Etsu& Takahashi, Masao& Oba, Shigeyoshi& Nishimatsu, Hiroaki. 2013. Oncogene- and Oxidative Stress-Induced Cellular Senescence Shows Distinct Expression Patterns of Proinflammatory Cytokines in Vascular Endothelial Cells. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1033275
Modern Language Association (MLA)
Suzuki, Etsu…[et al.]. Oncogene- and Oxidative Stress-Induced Cellular Senescence Shows Distinct Expression Patterns of Proinflammatory Cytokines in Vascular Endothelial Cells. The Scientific World Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1033275
American Medical Association (AMA)
Suzuki, Etsu& Takahashi, Masao& Oba, Shigeyoshi& Nishimatsu, Hiroaki. Oncogene- and Oxidative Stress-Induced Cellular Senescence Shows Distinct Expression Patterns of Proinflammatory Cytokines in Vascular Endothelial Cells. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1033275
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033275