AKT Kinase Pathway: A Leading Target in Cancer Research
Joint Authors
Kumar, Ambuj
Rajendran, Vidya
Sethumadhavan, Rao
Purohit, Rituraj
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
AKT1, a serine/threonine-protein kinase also known as AKT kinase, is involved in the regulation of various signalling downstream pathways including metabolism, cell proliferation, survival, growth, and angiogenesis.
The AKT kinases pathway stands among the most important components of cell proliferation mechanism.
Several approaches have been implemented to design an efficient drug molecule to target AKT kinases, although the promising results have not been confirmed.
In this paper we have documented the detailed molecular insight of AKT kinase protein and proposed a probable doxorubicin based approach in inhibiting miR-21 based cancer cell proliferation.
Moreover, the inhibition of miR-21 activation by raising the FOXO3A concentration seems promising in reducing miR-21 mediated cancer activation in cell.
Furthermore, the use of next generation sequencing and computational drug design approaches will greatly assist in designing a potent drug molecule against the associated cancer cases.
American Psychological Association (APA)
Kumar, Ambuj& Rajendran, Vidya& Sethumadhavan, Rao& Purohit, Rituraj. 2013. AKT Kinase Pathway: A Leading Target in Cancer Research. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1033276
Modern Language Association (MLA)
Kumar, Ambuj…[et al.]. AKT Kinase Pathway: A Leading Target in Cancer Research. The Scientific World Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1033276
American Medical Association (AMA)
Kumar, Ambuj& Rajendran, Vidya& Sethumadhavan, Rao& Purohit, Rituraj. AKT Kinase Pathway: A Leading Target in Cancer Research. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1033276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033276