Three-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma in Patients Unfit for Resection, Ablation, or Chemotherapy: A Retrospective Study
Joint Authors
Kelekis, Nikolaos
Zygogianni, Anna
Kouvaris, John
Antypas, Christos
Brountzos, Elias
Mosa, Eftychia
Georgakopoulos, John
Kosmidis, Paraskevas
Mystakidou, Kyriaki
Tolia, Maria
Beli, Ivelina
Gouliamos, Athanasios
Kouloulias, Vassilis
Platoni, Kalliopi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Purpose.
The purpose is to evaluate the feasibility, efficacy, and the toxicity of three-dimensional conformal radiotherapy (3DCRT) in patients with advanced hepatocelluar carcinoma (HCC) and inferior vena cava tumor thrombosis (IVCTT).
Methods.
Between 2007 and 2012, in a retrospective way, 9 patients (median age 69 years) with advanced HCC and IVCTT unfit for surgery, radiofrequency ablation, embolization, or chemotherapy were treated with three-dimensional conformal radiotherapy (3DCRT).
The radiotherapy volume included both primary tumor and IVTT.
The radiotherapy schedule was 50–52 Gy in 2 Gy fractions.
Overall survival (OS), response to radiotherapy, visual analogue scale (VAS), and toxicity were assessed.
Results.
All patients demonstrated a response rate up to 60%.
During radiotherapy, 3 patients experienced grade 1 nausea/vomit toxicity.
All patients demonstrated an elevation of the liver enzymes (3 patients with grade 1 and 6 patients with grade 2).
The mean VAS-score was decreased from 6.11 to 3.11, while the median overall survival was 24 months.
Conclusion.
3DCRT achieves a very high local control rate and is suitable for patients with HCC and IVTT, while the documented radiation induced toxicity is moderate.
It can be recommended for palliation in patients unable to undergo curative therapies.
American Psychological Association (APA)
Kouloulias, Vassilis& Mosa, Eftychia& Georgakopoulos, John& Platoni, Kalliopi& Brountzos, Elias& Zygogianni, Anna…[et al.]. 2013. Three-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma in Patients Unfit for Resection, Ablation, or Chemotherapy: A Retrospective Study. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1033290
Modern Language Association (MLA)
Kouloulias, Vassilis…[et al.]. Three-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma in Patients Unfit for Resection, Ablation, or Chemotherapy: A Retrospective Study. The Scientific World Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1033290
American Medical Association (AMA)
Kouloulias, Vassilis& Mosa, Eftychia& Georgakopoulos, John& Platoni, Kalliopi& Brountzos, Elias& Zygogianni, Anna…[et al.]. Three-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma in Patients Unfit for Resection, Ablation, or Chemotherapy: A Retrospective Study. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1033290
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033290