Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice
Joint Authors
Barreto, Rosana S. S.
Bonjardim, Leonardo Rigoldi
Souza, Grasielly Rocha
Silva, Juliane Cabral
Saraiva, Sarah Raquel Gomes de Lima
Júnior, Raimundo Gonçalves de Oliveira
Cavalcanti, Sócrates Cabral de Holanda
Quintans Júnior, Lucindo José
Almeida, Jackson Roberto Guedes da Silva
Quintans, Jullyana S. S.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Borneol, a bicyclic monoterpene, has been evaluated for antinociceptive and anti-inflammatory activities.
Antinociceptive and anti-inflammatory activities were studied by measuring nociception by acetic acid, formalin, hot plate, and grip strength tests, while inflammation was prompted by carrageenan-induced peritonitis.
The rotarod test was used to evaluate motor coordination.
Borneol produced a significant (P<0.01) reduction of the nociceptive behavior at the early and late phases of paw licking and reduced the writhing reflex in mice (formalin and writhing tests, resp.).
When the hot plate test was conducted, borneol (in higher dose) produced an inhibition (P<0.05) of the nociceptive behavior.
Such results were unlikely to be provoked by motor abnormality.
Additionally, borneol-treated mice reduced the carrageenan-induced leukocytes migration to the peritoneal cavity.
Together, our results suggest that borneol possess significant central and peripheral antinociceptive activity; it has also anti-inflammatory activity.
In addition, borneol did not impair motor coordination.
American Psychological Association (APA)
Almeida, Jackson Roberto Guedes da Silva& Souza, Grasielly Rocha& Silva, Juliane Cabral& Saraiva, Sarah Raquel Gomes de Lima& Júnior, Raimundo Gonçalves de Oliveira& Quintans, Jullyana S. S.…[et al.]. 2013. Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1033327
Modern Language Association (MLA)
Almeida, Jackson Roberto Guedes da Silva…[et al.]. Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1033327
American Medical Association (AMA)
Almeida, Jackson Roberto Guedes da Silva& Souza, Grasielly Rocha& Silva, Juliane Cabral& Saraiva, Sarah Raquel Gomes de Lima& Júnior, Raimundo Gonçalves de Oliveira& Quintans, Jullyana S. S.…[et al.]. Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1033327
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033327