Investigation of Chemokine Receptor CCR2V64Il Gene Polymorphism and Migraine without Aura in the Iranian Population
Joint Authors
Javanmard, Shaghayegh Haghjooy
Taheriun, Maryam
Soleimani, Samira
Zandifar, Alireza
Haghdoost, Faraidoon
Tajadini, Mohammadhasan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background and Objectives.
Migraine is a multifactorial common neurovascular disease with a polygenic inheritance.
Inflammation plays an important part in migraine pathophysiology.
C-C chemokine receptor 2 (CCR2) is an important chemokine for monocyte aggregation and transendothelial monocyte migration.
The aim of our study was to investigate the association of migraine with CCR2V64Il polymorphism in the Iranian population.
Methods.
We assessed 103 patients with newly diagnosed migraine and 100 healthy subjects.
Genomic DNA samples were extracted from peripheral blood and genotypes of CCR2V64Il gene polymorphism were determined.
For measuring the severity of headache, every patient filled out the MIGSEV questionnaire.
Results.
There were no significant differences in the distribution of both 64Il allele and heterozygote (GA) genotype of CCR2 gene polymorphism (P=0.396; OR=0.92, 95% CI = 0.50–1.67 and P=0.388; OR=0.91, 95% CI = 0.47–1.73, resp.) between case and control groups.
There was no significant difference of alleles frequency between three grades of MIGSEV (P=0.922).
Conclusions.
In conclusion our results revealed no association between CCR2V64Il polymorphism and susceptibility to migraine and also headache severity in the Iranian population.
American Psychological Association (APA)
Zandifar, Alireza& Taheriun, Maryam& Soleimani, Samira& Haghdoost, Faraidoon& Tajadini, Mohammadhasan& Javanmard, Shaghayegh Haghjooy. 2013. Investigation of Chemokine Receptor CCR2V64Il Gene Polymorphism and Migraine without Aura in the Iranian Population. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1033355
Modern Language Association (MLA)
Zandifar, Alireza…[et al.]. Investigation of Chemokine Receptor CCR2V64Il Gene Polymorphism and Migraine without Aura in the Iranian Population. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1033355
American Medical Association (AMA)
Zandifar, Alireza& Taheriun, Maryam& Soleimani, Samira& Haghdoost, Faraidoon& Tajadini, Mohammadhasan& Javanmard, Shaghayegh Haghjooy. Investigation of Chemokine Receptor CCR2V64Il Gene Polymorphism and Migraine without Aura in the Iranian Population. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1033355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033355