Is %ΔSUVmax a Useful Indicator of Survival in Patients with Advanced Nonsmall-Cell Lung Cancer?
Joint Authors
Fania, Piercarlo
Ficola, Umberto
Mojtahedi, Alireza
Filosso, Pier Luigi
Cucinotta, Mariapaola
Campennì, Alfredo
Baldari, Sergio
Cistaro, Angelina
Quartuccio, Natale
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-08
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Purpose.
To investigate the impact of the maximum standardized uptake value (SUVmax), size of primary lung lesion, and %ΔSUVmax on outcome (overall survival (OS) and 2-year disease-free survival (2-year DFS)) of patients with advanced nonsmall-cell lung cancer (NSCLC).
Materials and Methods.
86 stage III-IV NSCLC patients underwent 18 F-FDGPET/CT, before and after chemotherapy, and were classified into subgroups according to the response criteria of the European Organization for Research and Treatment of Cancer.
SUVmax values and tumor size with the best prognostic significance were searched.
Correlation between the SUVmax value and the initial response to therapy (best response) and the relationship between %ΔSUVmax and OS were assessed.
Results.
In patients in PD (20/86), the average pretreatment SUVmax was 11.8±5.23, and the mean size of the primary lesion was 43.35 mm±16.63.
In SD, PR, and CR patients (66/86), the average pretreatment SUVmax was 12.7±8.05, and the mean size of the primary lesion was 41.6 mm±21.15.
Correlation was identified only for %ΔSUVmax; patients with PD (ΔSUVmax > +25%) showed a worse OS than patients with ΔSUVmax < +25% (CR, PR, and SD) (P=0.0235).
Conclusions.
In stage III-IV NSCLC, among the assessed factors, only %ΔSUVmax may be considered as a useful prognostic factor.
American Psychological Association (APA)
Cistaro, Angelina& Quartuccio, Natale& Mojtahedi, Alireza& Fania, Piercarlo& Filosso, Pier Luigi& Cucinotta, Mariapaola…[et al.]. 2013. Is %ΔSUVmax a Useful Indicator of Survival in Patients with Advanced Nonsmall-Cell Lung Cancer?. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1033424
Modern Language Association (MLA)
Cistaro, Angelina…[et al.]. Is %ΔSUVmax a Useful Indicator of Survival in Patients with Advanced Nonsmall-Cell Lung Cancer?. The Scientific World Journal No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-1033424
American Medical Association (AMA)
Cistaro, Angelina& Quartuccio, Natale& Mojtahedi, Alireza& Fania, Piercarlo& Filosso, Pier Luigi& Cucinotta, Mariapaola…[et al.]. Is %ΔSUVmax a Useful Indicator of Survival in Patients with Advanced Nonsmall-Cell Lung Cancer?. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1033424
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033424