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Synthesis and Properties of Macrocyclic Butanoic Acid Conjugates as a Promising Delivery Formulation for the Nutrition of Colon
Joint Authors
Li, Benpeng
Ma, Peipei
Cheng, Jingui
Liu, Mengying
Wang, Zhizhong
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-18
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Butanoic acid plays a significant role in the maintenance of mucosal health and is the preferred energy substrate for the cells in the colon.
Here, butanoic acid was selectively conjugated to the secondary hydroxyl group of β-cyclodextrin through ester bond using sodium hydride as the deprotonation reagent.
The preliminary release behaviors of butanoic acid in rat gastrointestinal tract contents were investigated at 37°C within 12 h.
In the contents of stomach, the conjugates did seldom release butanoic acid, released butanoic acid only 5.8% in the contents of small intestine, and released butanoic acid significantly up to 38.4% in the contents of colon.
These results indicate that the conjugate activation took place site specifically in the rat colonic contents, via the biodegradation by glycosidases and hydrolases in the colon.
Therefore, the β-cyclodextrin conjugates of butanoic acid may be of value as an orally administered colon-specific formulation for the nutrition of colon.
American Psychological Association (APA)
Cheng, Jingui& Li, Benpeng& Ma, Peipei& Liu, Mengying& Wang, Zhizhong. 2013. Synthesis and Properties of Macrocyclic Butanoic Acid Conjugates as a Promising Delivery Formulation for the Nutrition of Colon. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1033426
Modern Language Association (MLA)
Cheng, Jingui…[et al.]. Synthesis and Properties of Macrocyclic Butanoic Acid Conjugates as a Promising Delivery Formulation for the Nutrition of Colon. The Scientific World Journal No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-1033426
American Medical Association (AMA)
Cheng, Jingui& Li, Benpeng& Ma, Peipei& Liu, Mengying& Wang, Zhizhong. Synthesis and Properties of Macrocyclic Butanoic Acid Conjugates as a Promising Delivery Formulation for the Nutrition of Colon. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1033426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033426