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Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma
Joint Authors
Vilen, Suvi-Tuuli
Nyberg, Pia
Salo, Tuula
Sorsa, Timo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
One hallmark of cancer is the degradation of the extracellular matrix (ECM), which is caused by proteinases.
In oral cancers, matrix metalloproteinases (MMPs), especially MMP-9, are associated with this degradation.
MMPs break down the ECM allowing cancer to spread; they also release various factors from their cryptic sites, including cytokines.
These factors modulate cell behavior and enhance cancer progression by regulating angiogenesis, migration, proliferation, and invasion.
The development of early metastases is typical for oral cancer, and increased MMP-9 expression is associated with a poor disease prognosis.
However, many studies fail to relate MMP-9 expression with metastasis formation.
Contrary to earlier models, recent studies show that MMP-9 plays a protective role in oral cancers.
Therefore, the role of MMP-9 is complicated and may fluctuate throughout the different types and stages of oral cancers.
American Psychological Association (APA)
Vilen, Suvi-Tuuli& Salo, Tuula& Sorsa, Timo& Nyberg, Pia. 2012. Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1033437
Modern Language Association (MLA)
Vilen, Suvi-Tuuli…[et al.]. Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma. The Scientific World Journal No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1033437
American Medical Association (AMA)
Vilen, Suvi-Tuuli& Salo, Tuula& Sorsa, Timo& Nyberg, Pia. Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma. The Scientific World Journal. 2012. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1033437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033437