MicroRNAs in Hepatocellular Carcinoma: Regulation, Function, and Clinical Implications
Joint Authors
Sun, Jie
Lu, Haiqi
Wang, Xian
Jin, Hongchuan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-04
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and the third cause of cancer-related death.
Poor understanding of the mechanisms underlying the pathogenesis of HCC makes it difficult to be diagnosed and treated at early stage.
MicroRNAs (miRNAs), a class of noncoding single-stranded RNAs of ~22 nucleotides in length, posttranscriptionally regulate gene expression by base pairing with the 3′ untranslated regions (3′UTRs) of target messenger RNAs (mRNAs).
Aberrant expression of miRNAs is found in many if not all cancers, and many deregulated miRNAs have been proved to play crucial roles in the initiation and progression of cancers by regulating the expression of various oncogenes or tumor suppressor genes.
In this Paper, we will summarize the regulations and functions of miRNAs aberrantly expressed in HCC and discuss the potential application of miRNAs as diagnostic and prognostic biomarkers of HCC and their potential roles in the intervention of HCC.
American Psychological Association (APA)
Sun, Jie& Lu, Haiqi& Wang, Xian& Jin, Hongchuan. 2013. MicroRNAs in Hepatocellular Carcinoma: Regulation, Function, and Clinical Implications. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1033442
Modern Language Association (MLA)
Sun, Jie…[et al.]. MicroRNAs in Hepatocellular Carcinoma: Regulation, Function, and Clinical Implications. The Scientific World Journal No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1033442
American Medical Association (AMA)
Sun, Jie& Lu, Haiqi& Wang, Xian& Jin, Hongchuan. MicroRNAs in Hepatocellular Carcinoma: Regulation, Function, and Clinical Implications. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1033442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033442