Effect of Polyunsaturated Fatty Acids on Homocysteine Metabolism through Regulating the Gene Expressions Involved in Methionine Metabolism
Joint Authors
Yang, Jing
Hu, Xiao-Jie
Li, Duo
Khan, Nicholas
Huang, Tao
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The objective was to investigate the regulatory effect of polyunsaturated fatty acids (PUFAs) on mRNA expression of key genes involved in homocysteine (Hcy) metabolism.
Eighty male Sprague Dawley rats were randomly divided into eight groups.
The oils were orally administered daily for 8 weeks.
Plasma Hcy, phospholipids fatty acids, and mRNA expression were determined.
Compared with the control group, plasma Hcy was significantly decreased in the 22:6n-3 and conjugated linoleic acid (CLA) groups; mRNA expression of Mthfr was significantly upregulated in the 22:6n-3, 20:5n-3, and 18:3n-3 groups and downregulated in the 18:2n-6 and stearolic acid (SO) groups.
Mat1a was upregulated in the 22:6n-3, 20:5n-3, 18:3n-3, and CLA groups.
In addition, Cbs was upregulated in the 22:6n-3, 20:5n-3, 18:3n-3 and CLA groups while downregulated in 18:2n-6 and SO groups.
Dietary 22:6n-3 and CLA decrease the plasma concentration of Hcy.
mRNA expression of Mthfr, Mat1a, Cbs and Pemt, Gnmt, Mtrr, and Bad is upregulated by n-3 PUFA and downregulated by n-6 PUFA.
CLA upregulates mRNA expression of Mat1a and Cbs.
American Psychological Association (APA)
Huang, Tao& Hu, Xiao-Jie& Khan, Nicholas& Yang, Jing& Li, Duo. 2013. Effect of Polyunsaturated Fatty Acids on Homocysteine Metabolism through Regulating the Gene Expressions Involved in Methionine Metabolism. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1033452
Modern Language Association (MLA)
Huang, Tao…[et al.]. Effect of Polyunsaturated Fatty Acids on Homocysteine Metabolism through Regulating the Gene Expressions Involved in Methionine Metabolism. The Scientific World Journal No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1033452
American Medical Association (AMA)
Huang, Tao& Hu, Xiao-Jie& Khan, Nicholas& Yang, Jing& Li, Duo. Effect of Polyunsaturated Fatty Acids on Homocysteine Metabolism through Regulating the Gene Expressions Involved in Methionine Metabolism. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1033452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033452