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Clinical Implications of Girdin Protein Expression in Glioma
Joint Authors
Zhao, Liwei
Ma, Shuyin
Liu, Qing
Liang, Peng
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Objective.
To investigate the expression status of Girdin in glioma and the relationship between Girdin expression and the biological behavior of glioma.
Materials and methods.
The expression status of Girdin in glioma from 560 cases was evaluated by RT-PCR, Western Blot and immunohistochemistry.
The relationship between Girdin expression and clinic-pathological parameters as well as prognosis was also studied.
Results.
The expression of Girdin in high grade glioma was significantly higher than low grade glioma.
After universal analysis, the expression of Girdin protein is closely related to KPS score, extent of resection, Ki67 and WHO grade, but it was not related to sex and age.
Finally, extent of resection, Ki67 and WHO grade were indentified to be related to the Girdin protein expression in logistic regression.
Interestingly, we found that the expression of Girdin is significantly related to the distant metastasis of glioma.
After COX regression analysis, KPS score, Extent of resection, Ki67, WHO grade as well as Girdin were observed to be independent prognostic factors.
Conclusions.
Girdin is differential expressed in the glioma patients and closely related to the biological behavior of Glioma.
Finally, Girdin was found to be a strong predictor for the post-operative prognosis.
American Psychological Association (APA)
Zhao, Liwei& Ma, Shuyin& Liu, Qing& Liang, Peng. 2013. Clinical Implications of Girdin Protein Expression in Glioma. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1033522
Modern Language Association (MLA)
Zhao, Liwei…[et al.]. Clinical Implications of Girdin Protein Expression in Glioma. The Scientific World Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1033522
American Medical Association (AMA)
Zhao, Liwei& Ma, Shuyin& Liu, Qing& Liang, Peng. Clinical Implications of Girdin Protein Expression in Glioma. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1033522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033522