Optimal (Control of) Intervention Strategies for Malaria Epidemic in Karonga District, Malawi
Joint Authors
Mwamtobe, Peter M.
Kasambara, Ansley
Tchuenche, Jean M.
Abelman, Shirley
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-19
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Malaria is a public health problem for more than 2 billion people globally.
About 219million cases of malaria occur worldwide and 660,000 people die, mostly (91%) in the AfricanRegion despite decades of efforts to control the disease.
Although the disease is preventable, itis life-threatening and parasitically transmitted by the bite of the female Anopheles mosquito.
A deterministic mathematical model with intervention strategies is developed in order toinvestigate the effectiveness and optimal control strategies of indoor residual spraying (IRS),insecticide treated nets (ITNs) and treatment on the transmission dynamics of malaria inKaronga District, Malawi.
The effective reproduction number is analytically computed,and the existence and stability conditions of the equilibria are explored.
The model doesnot exhibit backward bifurcation.
Pontryagin’s Maximum Principle which uses both theLagrangian and Hamiltonian principles with respect to a time dependent constant is used toderive the necessary conditions for the optimal control of the disease.
Numerical simulationsindicate that the prevention strategies lead to the reduction of both the mosquito populationand infected human individuals.
Effective treatment consolidates the prevention strategies.
Thus, malaria can be eradicated in Karonga District by concurrently applying vector control via ITNs and IRS complemented with timely treatment of infectedpeople.
American Psychological Association (APA)
Mwamtobe, Peter M.& Abelman, Shirley& Tchuenche, Jean M.& Kasambara, Ansley. 2014. Optimal (Control of) Intervention Strategies for Malaria Epidemic in Karonga District, Malawi. Abstract and Applied Analysis،Vol. 2014, no. 2014, pp.1-20.
https://search.emarefa.net/detail/BIM-1033856
Modern Language Association (MLA)
Mwamtobe, Peter M.…[et al.]. Optimal (Control of) Intervention Strategies for Malaria Epidemic in Karonga District, Malawi. Abstract and Applied Analysis No. 2014 (2014), pp.1-20.
https://search.emarefa.net/detail/BIM-1033856
American Medical Association (AMA)
Mwamtobe, Peter M.& Abelman, Shirley& Tchuenche, Jean M.& Kasambara, Ansley. Optimal (Control of) Intervention Strategies for Malaria Epidemic in Karonga District, Malawi. Abstract and Applied Analysis. 2014. Vol. 2014, no. 2014, pp.1-20.
https://search.emarefa.net/detail/BIM-1033856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033856