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Expression of EGFR and Molecules Downstream to PI3KAkt, Raf-1-MEK-1-MAP (Erk12), and JAK (STAT3) Pathways in Invasive Lung Adenocarcinomas Resected at a Single Institution
Joint Authors
Torres, Alba Fabiola
Nogueira, Cleto
Magalhaes, Juliana
Costa, Igor Santos
Aragao, Alessa
Neto, Antero Gomes
Martins, Filadelfia
Tavora, Fabio
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Therapies targeting EGFR are effective in treating tumors that harbor molecular alterations; however, there is heterogeneity in long-term response to these therapies.
We retrospectively analyzed protein expression of EGFR, Stat3, phospho-Akt, and phospho-Erk1/2 by immunohistochemistry in a series of resected cases from a single institution, correlated with clinicopathological variables.
There were 96 patients, with the majority of cases being of low stage tumors (17 pT1a, 23 pT1b, 30 pT2a, and 18 pT2b).
Histologic subtypes were 45 acinar predominant, 2 cribriform, 25 solid, 7 papillary, 11 lepidic, and 4 mucinous tumors.
The EGFR score was higher in tumors with vascular invasion ( P = 0.013 ), in solid and cribriform acinar histology, and in high stage tumors ( P = 0.006 and P = 0.01 ).
EGFR was more likely overexpressed in solid compared to lepidic tumors ( P = 0.02 ).
Acinar tumors had the highest rate of ERK1/2 positivity (19%).
There was a strong correlation among positivity for ERCC1 and other markers, including STAT3 ( P = 0.003 ), Akt ( P = 0.02 ), and ERK1/ERK2 ( P = 0.0005 ).
Expression of molecules downstream to EGFR varied from 12% to 31% of tumors; however, the expression did not directly correlate to EGFR expression, which may suggest activation of the cascades through different pathways.
The correlation of protein expression and the new lung adenocarcinoma classification may help in the understanding of activated pathways of each tumor type, which may act in the oncogenesis and drug resistance of these tumors.
American Psychological Association (APA)
Torres, Alba Fabiola& Nogueira, Cleto& Magalhaes, Juliana& Costa, Igor Santos& Aragao, Alessa& Neto, Antero Gomes…[et al.]. 2014. Expression of EGFR and Molecules Downstream to PI3KAkt, Raf-1-MEK-1-MAP (Erk12), and JAK (STAT3) Pathways in Invasive Lung Adenocarcinomas Resected at a Single Institution. Analytical Cellular Pathology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034178
Modern Language Association (MLA)
Torres, Alba Fabiola…[et al.]. Expression of EGFR and Molecules Downstream to PI3KAkt, Raf-1-MEK-1-MAP (Erk12), and JAK (STAT3) Pathways in Invasive Lung Adenocarcinomas Resected at a Single Institution. Analytical Cellular Pathology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1034178
American Medical Association (AMA)
Torres, Alba Fabiola& Nogueira, Cleto& Magalhaes, Juliana& Costa, Igor Santos& Aragao, Alessa& Neto, Antero Gomes…[et al.]. Expression of EGFR and Molecules Downstream to PI3KAkt, Raf-1-MEK-1-MAP (Erk12), and JAK (STAT3) Pathways in Invasive Lung Adenocarcinomas Resected at a Single Institution. Analytical Cellular Pathology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034178