Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells
Joint Authors
Cruz-Vega, Delia Elva
Duval, Florent
Rodríguez-Montalvo, Carlos
González-Garza, Maria Teresa
Moreno-Cuevas, Jorge E.
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Following chronic liver injury, hepatocytes undergo apoptosis leading to activation of hepatic stellate cells (HSC).
Consequently, activated HSC proliferate and produce excessive extracellular matrix, responsible for the scar formation.
The pandemic trend of obesity, combined with the high incidence of alcohol intake and viral hepatitis infections, highlights the urgent need to find accessible antifibrotic therapies.
Treatment strategies should take into account the versatility of its pathogenesis and act on all the cell lines involved to reduce liver fibrosis.
Medicinal plants are achieving popularity as antifibrotic agents, supported by their safety, cost-effectiveness, and versatility.
This review will describe the role of hepatocytes and HSC in the pathogenesis of liver fibrosis and detail the mechanisms of modulation of apoptosis of both cell lines by twelve known hepatoprotective plants in order to reduce liver fibrosis.
American Psychological Association (APA)
Duval, Florent& Moreno-Cuevas, Jorge E.& González-Garza, Maria Teresa& Rodríguez-Montalvo, Carlos& Cruz-Vega, Delia Elva. 2014. Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034360
Modern Language Association (MLA)
Duval, Florent…[et al.]. Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells. Advances in Pharmacological and Pharmaceutical Sciences No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1034360
American Medical Association (AMA)
Duval, Florent& Moreno-Cuevas, Jorge E.& González-Garza, Maria Teresa& Rodríguez-Montalvo, Carlos& Cruz-Vega, Delia Elva. Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells. Advances in Pharmacological and Pharmaceutical Sciences. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034360