Synthesis, Characterization, Semiempirical and Biological Activities of Organotin(IV) Carboxylates with 4-Piperidinecarboxylic Acid
Joint Authors
Shahzadi, Saira
Shahid, Muhammad
Hussain, Shabbir
Sharma, Saroj K.
Qanungo, Kushal
Ali, Saqib
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Organotin (IV) carboxylates with the general formulae R2Sn(Cl)L [R = Me (1), n-Bu (2), Ph (3)] and R3SnL [R = Me (4), Ph (5)] have been synthesized by the reaction of 4-piperidinecarboxylic acid (HL) with KOH and R2SnCl2 (R = Me, n-Bu, Ph)/R3SnCl (R = Me, Ph) in methanol under stirring conditions.
The metal ligand binding site, structure, and stability of complexes have been verified by FT-IR, (1H, 13C) NMR, EI-MS technique, and semiempirical study.
The FT-IR data indicate the bidentate chelating mode of the carboxylate ligand which is also confirmed by semiempirical study.
In solution state, five and four coordinated geometry around tin was confirmed by NMR spectroscopy.
The EI-MS data agreed well with the molecular structure of the complexes.
Thermodynamic parameters and molecular descriptors were calculated by using semiempirical PM3 method.
HOMO-LUMO calculations show that chlorodiorganotin complexes are more susceptible to nucleophilic attack as compared to triorganotin complexes.
Computed negative heat of formation indicates that complexes 1–4 are thermodynamically stable.
The organotin(IV) carboxylates displayed powerful antimicrobial activities against various strains of bacteria and fungi and their minimal inhibitory concentration were also evaluated.
The complexes exhibited comparatively higher hemolytic activity as compared to free ligand.
American Psychological Association (APA)
Hussain, Shabbir& Ali, Saqib& Shahzadi, Saira& Sharma, Saroj K.& Qanungo, Kushal& Shahid, Muhammad. 2014. Synthesis, Characterization, Semiempirical and Biological Activities of Organotin(IV) Carboxylates with 4-Piperidinecarboxylic Acid. Bioinorganic Chemistry and Applications،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034376
Modern Language Association (MLA)
Hussain, Shabbir…[et al.]. Synthesis, Characterization, Semiempirical and Biological Activities of Organotin(IV) Carboxylates with 4-Piperidinecarboxylic Acid. Bioinorganic Chemistry and Applications No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1034376
American Medical Association (AMA)
Hussain, Shabbir& Ali, Saqib& Shahzadi, Saira& Sharma, Saroj K.& Qanungo, Kushal& Shahid, Muhammad. Synthesis, Characterization, Semiempirical and Biological Activities of Organotin(IV) Carboxylates with 4-Piperidinecarboxylic Acid. Bioinorganic Chemistry and Applications. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034376