Relationship between CCR and NT-proBNP in Chinese HF Patients, and Their Correlations with Severity of HF
Joint Authors
Lu, Zhigang
Wang, Bo
Zheng, Wei
Wei, Meng
Qian, Xueqing
Wang, Yunliang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
To evaluate the relationship between creatinine clearance rate (CCR) and the level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure (HF) patients and their correlations with HF severity.
Methods and Results.
Two hundred and one Chinese patients were grouped according to the New York Heart Association (NYHA) classification as NYHA 1-2 and 3-4 groups and 135 cases out of heart failure patients as control group.
The following variables were compared among these three groups: age, sex, body mass index (BMI), smoking status, hypertension, diabetes, NT-proBNP, creatinine (Cr), uric acid (UA), left ventricular end-diastolic diameter (LVEDD), and CCR.
The biomarkers of NT-proBNP, Cr, UA, LVEDD, and CCR varied significantly in the three groups, and these variables were positively correlated with the NHYA classification.
The levels of NT-proBNP and CCR were closely related to the occurrence of HF and were independent risk factors for HF.
At the same time, there was a significant negative correlation between the levels of NT-proBNP and CCR.
The area under the receiver operating characteristic curve suggested that the NT-proBNP and CCR have high accuracy for diagnosis of HF and have clinical diagnostic value.
Conclusion.
NT-proBNP and CCR may be important biomarkers in evaluating the severity of HF.
American Psychological Association (APA)
Lu, Zhigang& Wang, Bo& Wang, Yunliang& Qian, Xueqing& Zheng, Wei& Wei, Meng. 2014. Relationship between CCR and NT-proBNP in Chinese HF Patients, and Their Correlations with Severity of HF. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034377
Modern Language Association (MLA)
Lu, Zhigang…[et al.]. Relationship between CCR and NT-proBNP in Chinese HF Patients, and Their Correlations with Severity of HF. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1034377
American Medical Association (AMA)
Lu, Zhigang& Wang, Bo& Wang, Yunliang& Qian, Xueqing& Zheng, Wei& Wei, Meng. Relationship between CCR and NT-proBNP in Chinese HF Patients, and Their Correlations with Severity of HF. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034377