Dynamic of the Cellular Immune Response at the Dermal Site of Leishmania (L.) amazonensis and Leishmania (V.) braziliensis Infection in Sapajus apella Primate
Joint Authors
Corbett, Carlos E. P.
Laurenti, Márcia Dalastra
Passero, Luiz Felipe Domingues
Tomokane, Thaise Yumie
Francesquini, Fernanda de Camargo
Rocha, Mussya Cisotto
Gomes, Claudia Maria de Castro
Silveira, Fernando Tobias
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The purpose of this study was to characterize the immunopathological response in the skin of S.
apella infected with Leishmania (L.) amazonensis and L.
(V.) braziliensis parasites, the main causative agents of localized cutaneous leishmaniasis in South America.
In infected animals, amastigote forms of L.
(L.) amazonensis could be detected till 120 days postinfection (PI), while, in L.
(V.) braziliensis infection, parasites could be detected until 180 days PI in the skin sections.
CD20+ cells were detected throughout the experimental time in both groups as well as in CD3+ cells, which appeared to be activated because high densities of inducible nitric oxide synthase (iNOS+) cells were detected at 60 and 90 days PI in both studied groups.
After 60 and 120 days PI, decrease in iNOS+ cells was observed in L.
(L.) amazonensis and L.
(V.) braziliensis, respectively, which was associated with parasite clearance.
Increase in lysozyme+ cells was observed during the experimental infections, which also can be associated with parasite killing.
American Psychological Association (APA)
Laurenti, Márcia Dalastra& Passero, Luiz Felipe Domingues& Tomokane, Thaise Yumie& Francesquini, Fernanda de Camargo& Rocha, Mussya Cisotto& Gomes, Claudia Maria de Castro…[et al.]. 2014. Dynamic of the Cellular Immune Response at the Dermal Site of Leishmania (L.) amazonensis and Leishmania (V.) braziliensis Infection in Sapajus apella Primate. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034382
Modern Language Association (MLA)
Laurenti, Márcia Dalastra…[et al.]. Dynamic of the Cellular Immune Response at the Dermal Site of Leishmania (L.) amazonensis and Leishmania (V.) braziliensis Infection in Sapajus apella Primate. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1034382
American Medical Association (AMA)
Laurenti, Márcia Dalastra& Passero, Luiz Felipe Domingues& Tomokane, Thaise Yumie& Francesquini, Fernanda de Camargo& Rocha, Mussya Cisotto& Gomes, Claudia Maria de Castro…[et al.]. Dynamic of the Cellular Immune Response at the Dermal Site of Leishmania (L.) amazonensis and Leishmania (V.) braziliensis Infection in Sapajus apella Primate. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034382