Clinical Outcome of Bortezomib Retreatment in Patients with Relapsed or Refractory Multiple Myeloma
Joint Authors
Lee, Seung-Shin
Ahn, Seo-Yeon
Yang, Deok-Hwan
Kim, Yeo-Kyeoung
Jung, Sung-Hoon
Ahn, Jae-Sook
Lee, Je-Jung
Kim, Hyeoung-Joon
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This retrospective study investigated the clinical efficacy and safety of bortezomib retreatment in patients with relapsed or refractory multiple myeloma (MM).
A total of 30 patients who relapsed or progressed after ≥6 months since the last dose of their previous bortezomib therapy were included in this study.
During the median 6 cycles (range: 2–12) of bortezomib retreatment, 10 (33.3%), 2 (6.7%), and 6 (20.0%) patients achieved complete response, very good partial response, and partial response, respectively.
Grade 3 or 4 neutropenia (47.0%), thrombocytopenia (43.0%), anemia (10.0%), and peripheral sensory neuropathy (3.0%) were observed.
The median time to progression, progression-free survival, and overall survival were 5.8 months (95% CI: 2.6–9.0), 5.5 months (95% CI: 4.2–6.8), and 13.4 months (95% CI: 6.1–20.7), respectively.
Patients who received bortezomib retreatment ≥12 months from initial last therapy had a 1-year OS rate of 65.8% (95% CI: 43.5–88.1) while patients receiving retreatment after 6–12 months interval had a 1-year OS rate of 41.7% (95% CI: 13.9–69.5) (P=0.038).
In conclusion, this study demonstrates that retreatment with bortezomib is an effective strategy for patients with MM who relapsed at a long interval after initial bortezomib therapy.
American Psychological Association (APA)
Ahn, Jae-Sook& Jung, Sung-Hoon& Lee, Seung-Shin& Ahn, Seo-Yeon& Yang, Deok-Hwan& Kim, Yeo-Kyeoung…[et al.]. 2014. Clinical Outcome of Bortezomib Retreatment in Patients with Relapsed or Refractory Multiple Myeloma. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034384
Modern Language Association (MLA)
Ahn, Jae-Sook…[et al.]. Clinical Outcome of Bortezomib Retreatment in Patients with Relapsed or Refractory Multiple Myeloma. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1034384
American Medical Association (AMA)
Ahn, Jae-Sook& Jung, Sung-Hoon& Lee, Seung-Shin& Ahn, Seo-Yeon& Yang, Deok-Hwan& Kim, Yeo-Kyeoung…[et al.]. Clinical Outcome of Bortezomib Retreatment in Patients with Relapsed or Refractory Multiple Myeloma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034384